Pathophysiology of chronic graft-versus-host disease and therapeutic targets

R Zeiser, BR Blazar - New England Journal of Medicine, 2017 - Mass Medical Soc
Chronic GVHD, an autoimmune disease that follows allogeneic hematopoietic-cell
transplantation, is characterized by infections and debilitating tissue injury leading to …

Classification systems for chronic graft-versus-host disease

SJ Lee - Blood, The Journal of the American Society of …, 2017 - ashpublications.org
Chronic graft versus host disease (GVHD) is a major cause of morbidity and mortality after
allogeneic hematopoietic cell transplantation. Clinically, chronic GVHD is a pleiotropic …

[HTML][HTML] Ruxolitinib for glucocorticoid-refractory chronic graft-versus-host disease

R Zeiser, N Polverelli, R Ram, SK Hashmi… - … England Journal of …, 2021 - Mass Medical Soc
Background Chronic graft-versus-host disease (GVHD), a major complication of allogeneic
stem-cell transplantation, becomes glucocorticoid-refractory or glucocorticoid-dependent in …

[HTML][HTML] National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: I. The 2014 Diagnosis and …

MH Jagasia, HT Greinix, M Arora, KM Williams… - Biology of Blood and …, 2015 - Elsevier
Abstract The 2005 National Institutes of Health (NIH) Consensus Conference proposed new
criteria for diagnosing and scoring the severity of chronic graft-versus-host disease (GVHD) …

ROCK2 inhibition with belumosudil (KD025) for the treatment of chronic graft-versus-host disease

M Jagasia, A Lazaryan, CR Bachier… - Journal of Clinical …, 2021 - ascopubs.org
PURPOSE The rho-associated coiled-coil–containing protein kinase-2 (ROCK2) signaling
pathway regulates the Th17/regulatory T cells balance and controls profibrotic pathways …

Interleukin-2 and regulatory T cells in graft-versus-host disease

J Koreth, K Matsuoka, HT Kim… - … England Journal of …, 2011 - Mass Medical Soc
Background Dysfunction of regulatory T (Treg) cells has been detected in diverse
inflammatory disorders, including chronic graft-versus-host disease (GVHD). Interleukin-2 is …

[HTML][HTML] National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: IIa. The 2020 clinical …

CL Kitko, J Pidala, HM Schoemans… - … and cellular therapy, 2021 - Elsevier
Recognition of the earliest signs and symptoms of chronic graft-versus-host disease (GVHD)
that lead to severe manifestations remains a challenge. The standardization provided by the …

[HTML][HTML] Measuring therapeutic response in chronic graft-versus-host disease. National Institutes of Health consensus development project on criteria for clinical trials …

SJ Lee, D Wolff, C Kitko, J Koreth, Y Inamoto… - Biology of Blood and …, 2015 - Elsevier
Abstract In 2005, the National Institutes of Health (NIH) Chronic Graft-versus-Host Disease
(GVHD) Consensus Response Criteria Working Group recommended several measures to …

How we treat chronic graft-versus-host disease

MED Flowers, PJ Martin - Blood, The Journal of the American …, 2015 - ashpublications.org
Chronic graft-versus-host disease (GVHD) remains a common and potentially life-
threatening complication of allogeneic hematopoietic stem cell transplantation (HCT). The 2 …

Current issues in chronic graft-versus-host disease

G Socié, J Ritz - Blood, The Journal of the American Society of …, 2014 - ashpublications.org
Chronic graft-versus-host disease (GVHD) is a frequent and potentially life-threatening
complication of allogeneic hematopoietic stem cell transplantation. Increased …