Pathophysiology of chronic graft-versus-host disease and therapeutic targets
Chronic GVHD, an autoimmune disease that follows allogeneic hematopoietic-cell
transplantation, is characterized by infections and debilitating tissue injury leading to …
transplantation, is characterized by infections and debilitating tissue injury leading to …
Classification systems for chronic graft-versus-host disease
SJ Lee - Blood, The Journal of the American Society of …, 2017 - ashpublications.org
Chronic graft versus host disease (GVHD) is a major cause of morbidity and mortality after
allogeneic hematopoietic cell transplantation. Clinically, chronic GVHD is a pleiotropic …
allogeneic hematopoietic cell transplantation. Clinically, chronic GVHD is a pleiotropic …
[HTML][HTML] Ruxolitinib for glucocorticoid-refractory chronic graft-versus-host disease
Background Chronic graft-versus-host disease (GVHD), a major complication of allogeneic
stem-cell transplantation, becomes glucocorticoid-refractory or glucocorticoid-dependent in …
stem-cell transplantation, becomes glucocorticoid-refractory or glucocorticoid-dependent in …
[HTML][HTML] National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: I. The 2014 Diagnosis and …
MH Jagasia, HT Greinix, M Arora, KM Williams… - Biology of Blood and …, 2015 - Elsevier
Abstract The 2005 National Institutes of Health (NIH) Consensus Conference proposed new
criteria for diagnosing and scoring the severity of chronic graft-versus-host disease (GVHD) …
criteria for diagnosing and scoring the severity of chronic graft-versus-host disease (GVHD) …
ROCK2 inhibition with belumosudil (KD025) for the treatment of chronic graft-versus-host disease
M Jagasia, A Lazaryan, CR Bachier… - Journal of Clinical …, 2021 - ascopubs.org
PURPOSE The rho-associated coiled-coil–containing protein kinase-2 (ROCK2) signaling
pathway regulates the Th17/regulatory T cells balance and controls profibrotic pathways …
pathway regulates the Th17/regulatory T cells balance and controls profibrotic pathways …
Interleukin-2 and regulatory T cells in graft-versus-host disease
Background Dysfunction of regulatory T (Treg) cells has been detected in diverse
inflammatory disorders, including chronic graft-versus-host disease (GVHD). Interleukin-2 is …
inflammatory disorders, including chronic graft-versus-host disease (GVHD). Interleukin-2 is …
[HTML][HTML] National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: IIa. The 2020 clinical …
CL Kitko, J Pidala, HM Schoemans… - … and cellular therapy, 2021 - Elsevier
Recognition of the earliest signs and symptoms of chronic graft-versus-host disease (GVHD)
that lead to severe manifestations remains a challenge. The standardization provided by the …
that lead to severe manifestations remains a challenge. The standardization provided by the …
[HTML][HTML] Measuring therapeutic response in chronic graft-versus-host disease. National Institutes of Health consensus development project on criteria for clinical trials …
Abstract In 2005, the National Institutes of Health (NIH) Chronic Graft-versus-Host Disease
(GVHD) Consensus Response Criteria Working Group recommended several measures to …
(GVHD) Consensus Response Criteria Working Group recommended several measures to …
How we treat chronic graft-versus-host disease
MED Flowers, PJ Martin - Blood, The Journal of the American …, 2015 - ashpublications.org
Chronic graft-versus-host disease (GVHD) remains a common and potentially life-
threatening complication of allogeneic hematopoietic stem cell transplantation (HCT). The 2 …
threatening complication of allogeneic hematopoietic stem cell transplantation (HCT). The 2 …
Current issues in chronic graft-versus-host disease
Chronic graft-versus-host disease (GVHD) is a frequent and potentially life-threatening
complication of allogeneic hematopoietic stem cell transplantation. Increased …
complication of allogeneic hematopoietic stem cell transplantation. Increased …