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DNA microarrays are a well-established technology for measuring gene expression levels.
Microarrays designed for this purpose use relatively few probes for each gene and are …

The stem cells that maintain and repair the postnatal skeleton remain undefined. One model
suggests that perisinusoidal mesenchymal stem cells (MSCs) give rise to osteoblasts …

High-throughput and high-content databases are increasingly important resources in
molecular medicine, systems biology, and pharmacology. However, the information usually …

Replicative cellular senescence is an important tumor suppression mechanism and also
contributes to aging. Progression of both cancer and aging include significant epigenetic …

High-density oligonucleotide expression arrays are widely used in many areas of
biomedical research. Affymetrix GeneChip arrays are the most popular. In the Affymetrix …

Background Several recent studies have demonstrated the effectiveness of deep
sequencing for transcriptome analysis (RNA-seq) in mammals. As RNA-seq becomes more …

There is abundant transcription from eukaryotic genomes unaccounted for by protein coding
genes. A high-resolution genome-wide survey of transcription in a well annotated genome …

Background Monocytes and macrophages express an extensive repertoire of G Protein-
Coupled Receptors (GPCRs) that regulate inflammation and immunity. In this study we …

The diurnal variation in the incidence of myocardial infarction and stroke may reflect an
influence of the molecular clock and/or the time dependence of exposure to environmental …