Significance: Among different forms of oxidative stress, lipid peroxidation comprises the
interaction of free radicals with polyunsaturated fatty acids, which in turn leads to the …

Several studies demonstrated that oxidative damage is a characteristic feature of many
neurodegenerative diseases. The accumulation of oxidatively modified proteins may disrupt …

Alzheimer's disease (AD) is the most important cause of dementia in the elderly. The
molecular alterations preceding this neurodegenerative pathology may take place even 20 …

Biomarkers for neurodegenerative disorders are essential to facilitate disease diagnosis,
ideally at early stages, monitor disease progression, and assess response to existing and …

Epilepsy afflicts up to 1.6% of the population and the mechanisms underlying the
appearance of seizures are still not understood. In past years, many efforts have been spent …

Abstract Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a ubiquitous enzyme that
catalyzes the sixth step of glycolysis and thus, serves to break down glucose for energy …

Background Synaptic alterations, especially presynaptic changes, are cardinal features of
neurodegenerative diseases and strongly correlate with cognitive decline. New method We …

Cognitive impairment, including dementia, is commonly seen in those afflicted with
Parkinson disease (PD), particularly at advanced disease stages. Pathologically, PD with …

Identification of reliable and robust biomarkers is crucial to enable early diagnosis of
Parkinson disease (PD) and monitoring disease progression. While imperfect, the slow …

Temporal lobe epilepsy is triggered by an initial insult, such as status epilepticus, that
initiates the process of epilepsy development. Heat shock protein 70 (Hsp70) is a …