[HTML][HTML] Selected biomarkers of depression: what are the effects of cytokines and inflammation?

S Harsanyi, I Kupcova, L Danisovic, M Klein - International journal of …, 2022 - mdpi.com
Depression is one of the leading mental illnesses worldwide and lowers the quality of life of
many. According to WHO, about 5% of the worldwide population suffers from depression …

[HTML][HTML] Molecular mechanisms underlying the antidepressant actions of arketamine: beyond the NMDA receptor

Y Wei, L Chang, K Hashimoto - Molecular Psychiatry, 2022 - nature.com
The discovery of robust antidepressant actions exerted by the N-methyl-D-aspartate receptor
(NMDAR) antagonist (R, S)-ketamine has been a crucial breakthrough in mood disorder …

[HTML][HTML] A path toward precision medicine for neuroinflammatory mechanisms in Alzheimer's disease

H Hampel, F Caraci, AC Cuello, G Caruso… - Frontiers in …, 2020 - frontiersin.org
Neuroinflammation commences decades before Alzheimer's disease (AD) clinical onset and
represents one of the earliest pathomechanistic alterations throughout the AD continuum …

Polyphenols and neuroprotection: Therapeutic implications for cognitive decline

G Caruso, SA Torrisi, MP Mogavero, W Currenti… - Pharmacology & …, 2022 - Elsevier
Dietary polyphenols have been the focus of major interest for their potential benefits on
human health. Several preclinical studies have been conducted to provide a rationale for …

[HTML][HTML] Diet and mental health: Review of the recent updates on molecular mechanisms

J Godos, W Currenti, D Angelino, P Mena, S Castellano… - Antioxidants, 2020 - mdpi.com
Over the last decades, there has been a substantial increase in the prevalence of mental
health disorders, including an increased prevalence of depression, anxiety, cognitive, and …

Ketamine and its metabolites: Potential as novel treatments for depression

K Zhang, Y Yao, K Hashimoto - Neuropharmacology, 2023 - Elsevier
Depression is a well-known serious mental illness, and the onset of treatment using
traditional antidepressants is frequently delayed by several weeks. Moreover, numerous …

[HTML][HTML] Cytokine research in depression: principles, challenges, and open questions

H Himmerich, O Patsalos, N Lichtblau… - Frontiers in …, 2019 - frontiersin.org
Cytokines have been implicated in the pathology of depression. Currently, the evidence is
based on cross-sectional studies and meta-analytic research comparing blood …

Depression, dementia and immune dysregulation

S Hayley, AM Hakim, PR Albert - Brain, 2021 - academic.oup.com
Major depression is a prevalent illness that increases the risk of several neurological
conditions. These include stroke, cardiovascular disease, and dementia including …

[HTML][HTML] Microglia, lifestyle stress, and neurodegeneration

C Madore, Z Yin, J Leibowitz, O Butovsky - Immunity, 2020 - cell.com
Recent years have witnessed a revolution in our understanding of microglia biology,
including their major role in the etiology and pathogenesis of neurodegenerative diseases …

[HTML][HTML] Pathways connecting late-life depression and dementia

C Linnemann, UE Lang - Frontiers in pharmacology, 2020 - frontiersin.org
Late-life depression is associated with significant cognitive impairment. Meta-analyses
showed that depression is associated with an increased risk for Alzheimer's disease (AD) …