Host genetic factors determining COVID-19 susceptibility and severity

TP Velavan, SR Pallerla, J Rüter, Y Augustin… - …, 2021 - thelancet.com
The COVID-19 pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus-2
(SARS-CoV-2) poses an unprecedented challenge to humanity. SARS-CoV-2 infections …

Risk factors of severe COVID-19: a review of host, viral and environmental factors

L Zsichla, V Müller - Viruses, 2023 - mdpi.com
The clinical course and outcome of COVID-19 are highly variable, ranging from
asymptomatic infections to severe disease and death. Understanding the risk factors of …

Novel genes and sex differences in COVID-19 severity

R Cruz, S Diz-de Almeida… - Human Molecular …, 2022 - academic.oup.com
Here, we describe the results of a genome-wide study conducted in 11 939 coronavirus
disease 2019 (COVID-19) positive cases with an extensive clinical information that were …

Andrological effects of SARS-Cov-2 infection: a systematic review and meta-analysis

G Corona, W Vena, A Pizzocaro, F Pallotti… - Journal of …, 2022 - Springer
Purpose The short-and long-term andrological effects of coronavirus disease 2019 (COVID-
19) have not been clarified. Our aim is to evaluate the available evidence regarding possible …

The relationship of serum testosterone levels with the clinical course and prognosis of COVID‐19 disease in male patients: a prospective study

AE Cinislioglu, N Cinislioglu, SO Demirdogen… - …, 2022 - Wiley Online Library
Background A potential role of testosterone among sex hormones has been hypothesized in
identifying sex‐related differences in the clinical consequences of severe acute respiratory …

Gender-specific impact of sex hormones on the immune system

F Sciarra, F Campolo, E Franceschini… - International journal of …, 2023 - mdpi.com
Sex hormones are key determinants of gender-related differences and regulate growth and
development during puberty. They also exert a broad range modulation of immune cell …

The association of COVID-19 severity and susceptibility and genetic risk factors: A systematic review of the literature

A Ishak, M Mehendale, MM AlRawashdeh… - Gene, 2022 - Elsevier
Background COVID-19 is associated with several risk factors such as distinct ethnicities
(genetic ancestry), races, sexes, age, pre-existing comorbidities, smoking, and genetics. The …

Testosterone and Covid‐19: an update

A Yassin, R Shabsigh, RM Al‐Zoubi… - Reviews in Medical …, 2023 - Wiley Online Library
There is overwhelming evidence to suggest that male gender is at a higher risk of
developing more severe Covid‐19 disease and thus having poorer clinical outcomes …

[HTML][HTML] Role of testosterone in SARS-CoV-2 infection: A key pathogenic factor and a biomarker for severe pneumonia

M Camici, P Zuppi, P Lorenzini, L Scarnecchia… - International Journal of …, 2021 - Elsevier
Objectives To investigate the association between sex hormones and the severity of
coronavirus disease 2019 (COVID-19). Furthermore, associations between sex hormones …

[HTML][HTML] Testosterone in COVID-19: an adversary bane or comrade boon

HM Al-Kuraishy, AI Al-Gareeb, H Faidah… - Frontiers in cellular …, 2021 - frontiersin.org
COVID-19 is a pandemic disease caused by severe acute respiratory coronavirus 2 (SARS-
CoV-2), which leads to pulmonary manifestations like acute lung injury (ALI) and acute …