The mitochondrial DNA (mtDNA) m. 3243A> G mutation is one of the most common
pathogenic mtDNA variants, showing complex genetics, pathogenic molecular mechanisms …

Background and Objectives Stroke management in the context of primary mitochondrial
disease is clinically challenging, and the best treatment options for patients with stroke-like …

Mitochondrial diseases, caused by mutations in either the nuclear or mitochondrial genomes
(mtDNA), are the most common form of inherited neurometabolic disorders. They are …

Background Electrolyte reabsorption in the kidney has a high energy demand. Proximal and
distal tubular epithelial cells have a high mitochondrial density for energy release. Recently …

Mitochondrial diseases are the most common inheritable metabolic diseases, due to defects
in oxidative phosphorylation. They are caused by mutations of nuclear or mitochondrial DNA …

Mitochondrial stroke-like episodes (SLEs) are a hallmark of mitochondrial
encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS). They should be …

Stroke-like episode is a paroxysmal neurological manifestation which affects a specific
group of patients with mitochondrial disease. Focal-onset seizures, encephalopathy, and …

Although not often discussed, many of the neuromuscular disorders (NMDs) affect the
gastrointestinal tract (GIT). Depending on the type of NMD, the prevalence of GIT …

Background Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes
(MELAS) syndrome is a systemic disorder in which multi-organ dysfunction may occur from …

Letter to the Editor We read with interest Guerrero-Molina et al.'s article on a controlled,
prospective, open-label, single-centre study of cerebral concentrations of glutamine and …