Neuroinflammation induced by lipopolysaccharide causes cognitive impairment in mice

J Zhao, W Bi, S Xiao, X Lan, X Cheng, J Zhang, D Lu… - Scientific reports, 2019 - nature.com
In this study, we investigated lipopolysaccharide (LPS)-induced cognitive impairment and
neuroinflammation in C57BL/6J mice by using behavioral tests, immunofluorescence …

AIF1: function and connection with inflammatory diseases

D De Leon-Oliva, C Garcia-Montero, O Fraile-Martinez… - Biology, 2023 - mdpi.com
Simple Summary Allograft inflammatory factor 1 (AIF1) is a calcium-binding protein that
participates in intracellular processes such as phagocytosis, membrane ruffling and F-actin …

Macrophages: an elusive yet emerging therapeutic target of atherosclerosis

RL Tiwari, V Singh, MK Barthwal - Medicinal research reviews, 2008 - Wiley Online Library
Macrophages are central to the initiation and progression of atherosclerosis and thus can be
very appropriate targets for therapy. Cell adhesion molecules mediating monocytes …

T cell costimulation blockade blunts pressure overload-induced heart failure

M Kallikourdis, E Martini, P Carullo, C Sardi… - Nature …, 2017 - nature.com
Heart failure (HF) is a leading cause of mortality. Inflammation is implicated in HF, yet clinical
trials targeting pro-inflammatory cytokines in HF were unsuccessful, possibly due to …

The potential ameliorative impacts of cerium oxide nanoparticles against fipronil-induced hepatic steatosis

L Wasef, AMK Nassar, YS El-Sayed, D Samak… - Scientific reports, 2021 - nature.com
Fipronil (FIP) is a phenylpyrazole insecticide that is commonly used in agricultural and
veterinary fields for controlling a wide range of insects, but it is a strong environmentally toxic …

Role of AIF-1 in the regulation of inflammatory activation and diverse disease processes

YY Zhao, DJ Yan, ZW Chen - Cellular immunology, 2013 - Elsevier
Abstract Allograft Inflammatory Factor-1 (AIF-1) is a 17 kDa cytoplasmic, calcium-binding,
inflammation-responsive scaffold protein that is mainly expressed in immunocytes. AIF-1 …

Allograft inflammatory factor-1/Ionized calcium-binding adapter molecule 1 is specifically expressed by most subpopulations of macrophages and spermatids in testis

C Köhler - Cell and tissue research, 2007 - Springer
Ionized calcium-binding adapter molecule 1 (Iba1) is a 147-amino-acid calcium-binding
protein widely in use as a marker for microglia. It has actin-crosslinking activity and is …

Effects of the fibroblast activation protein inhibitor, PT100, in a murine model of pulmonary fibrosis

C Egger, C Cannet, C Gérard, T Suply, I Ksiazek… - European journal of …, 2017 - Elsevier
Bleomycin (BLM) induced lung injury is detectable in C57BL/6 mice using magnetic
resonance imaging (MRI). We investigated the effects of the fibroblast activation protein …

[HTML][HTML] The role of tumor-associated macrophages in primary hepatocellular carcinoma and its related targeting therapy

L Deng, K He, Y Pan, H Wang, Y Luo… - International Journal of …, 2021 - ncbi.nlm.nih.gov
Liver macrophages consist of ontogenically distinct populations termed Kupffer cells and
monocyte-derived macrophages. Tumor-associated macrophages (TAMs) …

Acetaminophen-induced rat hepatotoxicity based on M1/M2-macrophage polarization, in possible relation to damage-associated molecular patterns and autophagy

Y Tsuji, M Kuramochi, HM Golbar, T Izawa… - International Journal of …, 2020 - mdpi.com
Overdose of acetaminophen (APAP), an antipyretic drug, is an important cause of liver
injury. However, the mechanism in the rat model remains undetermined. We analyzed APAP …