Background Asthma is a respiratory (airway) condition that affects an estimated 300 million
people worldwide and is associated with significant morbidity and mortality. Omalizumab is …

Mast cells and their mediators have been implicated in the pathogenesis of asthma and
allergy for decades. Allergic asthma is a complex chronic lung disease in which several …

Background Diagnosing asthma in children represents an important clinical challenge.
There is no single gold-standard test to confirm the diagnosis. Consequently, over-and …

Background Onset of allergic asthma has a strong association with childhood but only a few
studies have analyzed incidence of asthma from childhood to late adulthood in relation to …

Allergic rhinitis is a symptomatic disorder of the nose induced after allergen exposure by an
immunoglobulin E (IgE)-mediated inflammation of the membranes lining the nose (1). It was …

The discovery of IgE represented a major breakthrough in allergy and asthma research,
whereas the clinical interest given to IgE in asthma has been blurred until the arrival of anti …

Background Many young children wheeze during viral respiratory infections, but the
pathogenesis of these episodes and their relation to the development of asthma later in life …

Methods This paper arose from an extensive literature review undertaken in developing the
Canadian Healthy Infant Longitudinal Development (CHILD) study, a multicentre national …

Background The relation between lower respiratory tract illnesses in early life caused by the
respiratory syncytial virus (RSV) and the subsequent development of wheezing and atopy in …

BACKGROUND: Measurement of biomarkers has been incorporated within clinical research
studies of asthma to characterize the population and associate the disease with …