Macrophage phenotype and function in different stages of atherosclerosis
I Tabas, KE Bornfeldt - Circulation research, 2016 - Am Heart Assoc
The remarkable plasticity and plethora of biological functions performed by macrophages
have enticed scientists to study these cells in relation to atherosclerosis for> 50 years, and …
have enticed scientists to study these cells in relation to atherosclerosis for> 50 years, and …
[HTML][HTML] Cytokines in atherosclerosis: Key players in all stages of disease and promising therapeutic targets
Atherosclerosis, a chronic inflammatory disorder of the arteries, is responsible for most
deaths in westernized societies with numbers increasing at a marked rate in developing …
deaths in westernized societies with numbers increasing at a marked rate in developing …
Microanatomy of the human atherosclerotic plaque by single-cell transcriptomics
MAC Depuydt, KHM Prange, L Slenders, T Örd… - Circulation …, 2020 - Am Heart Assoc
Rationale: Atherosclerotic lesions are known for their cellular heterogeneity, yet the
molecular complexity within the cells of human plaques has not been fully assessed …
molecular complexity within the cells of human plaques has not been fully assessed …
Neutrophil extracellular traps license macrophages for cytokine production in atherosclerosis
A Warnatsch, M Ioannou, Q Wang, V Papayannopoulos - Science, 2015 - science.org
Secretion of the cytokine interleukin-1β (IL-1β) by macrophages, a major driver of
pathogenesis in atherosclerosis, requires two steps: Priming signals promote transcription of …
pathogenesis in atherosclerosis, requires two steps: Priming signals promote transcription of …
[HTML][HTML] Single-cell analysis of fate-mapped macrophages reveals heterogeneity, including stem-like properties, during atherosclerosis progression and regression
Atherosclerosis is a leading cause of death worldwide in industrialized countries. Disease
progression and regression are associated with different activation states of macrophages …
progression and regression are associated with different activation states of macrophages …
Atherosclerosis: current pathogenesis and therapeutic options
Coronary artery disease (CAD) arising from atherosclerosis is a leading cause of death and
morbidity worldwide. The underlying pathogenesis involves an imbalanced lipid metabolism …
morbidity worldwide. The underlying pathogenesis involves an imbalanced lipid metabolism …
Macrophage subsets in atherosclerosis as defined by single‐cell technologies
L Willemsen, MPJ de Winther - The Journal of pathology, 2020 - Wiley Online Library
Macrophages play a major role in the pathogenesis of atherosclerosis. Many studies have
shone light on the different phenotypes and functions that macrophages can acquire upon …
shone light on the different phenotypes and functions that macrophages can acquire upon …
Macrophages in the pathogenesis of atherosclerosis
In atherosclerosis, the accumulation of apolipoprotein B-lipoproteins in the matrix beneath
the endothelial cell layer of blood vessels leads to the recruitment of monocytes, the cells of …
the endothelial cell layer of blood vessels leads to the recruitment of monocytes, the cells of …
NF-κB, inflammation, and metabolic disease
Metabolic disorders including obesity, type 2 diabetes, and atherosclerosis have been
viewed historically as lipid storage disorders brought about by overnutrition. It is now widely …
viewed historically as lipid storage disorders brought about by overnutrition. It is now widely …
DNA methyltransferase 3 alpha and TET methylcytosine dioxygenase 2 restrain mitochondrial DNA-mediated interferon signaling in macrophages
Deleterious somatic mutations in DNA methyltransferase 3 alpha (DNMT3A) and TET
mehtylcytosine dioxygenase 2 (TET2) are associated with clonal expansion of …
mehtylcytosine dioxygenase 2 (TET2) are associated with clonal expansion of …