Glioblastoma Multiforme—A Look at the Past and a Glance at the Future

JL King, SR Benhabbour - Pharmaceutics, 2021 - mdpi.com
Gliomas are the most common type of brain tumor that occur in adults and children.
Glioblastoma multiforme (GBM) is the most common, aggressive form of brain cancer in …

Cell-based therapy for the treatment of glioblastoma: an update from preclinical to clinical studies

N Attia, M Mashal, S Pemminati, A Omole… - Cells, 2021 - mdpi.com
Glioblastoma (GB), an aggressive primary tumor of the central nervous system, represents
about 60% of all adult primary brain tumors. It is notorious for its extremely low (~ 5%) 5-year …

[HTML][HTML] Safety and biodistribution of exosomes derived from human induced pluripotent stem cells

Z Gu, Z Yin, P Song, Y Wu, Y He, M Zhu… - … in Bioengineering and …, 2022 - frontiersin.org
As a new cell-free therapy, exosomes have provided new ideas for the treatment of various
diseases. Human induced pluripotent stem cells (hiPSCs) cannot be used in clinical trials …

Injectable pH thermo-responsive hydrogel scaffold for tumoricidal neural stem cell therapy for glioblastoma multiforme

JL King, P Maturavongsadit, SD Hingtgen… - Pharmaceutics, 2022 - mdpi.com
Glioblastoma multiforme (GBM) is the most common malignant brain tumor in adults and
despite recent advances in treatment modalities, GBM remains incurable. Injectable …

Tracking neural stem cells in vivo: achievements and limitations

CR Xue, K Wang, MZ Zhang, Z Wang, YY Song… - Stem Cell Reviews and …, 2022 - Springer
Neural stem cell (NSC) therapies are developing rapidly and have been proposed as a
treatment option for various neurological diseases, such as stroke, Parkinson's disease and …

[HTML][HTML] High-content screening and analysis of stem cell-derived neural interfaces using a combinatorial nanotechnology and machine learning approach

L Yang, BM Conley, J Yoon, C Rathnam, T Pongkulapa… - Research, 2022 - spj.science.org
A systematic investigation of stem cell-derived neural interfaces can facilitate the discovery
of the molecular mechanisms behind cell behavior in neurological disorders and accelerate …

Spatiotemporal analysis of induced neural stem cell therapy to overcome advanced glioblastoma recurrence

AB Satterlee, DE Dunn, A Valdivia, D Malawsky… - Molecular Therapy …, 2022 - cell.com
Genetically engineered neural stem cells (NSCs) are a promising therapy for the highly
aggressive brain cancer glioblastoma (GBM); however, treatment durability remains a major …

Intravenously infused stem cells for cancer treatment

AR Mercer-Smith, IA Findlay, HN Bomba… - Stem cell reviews and …, 2021 - Springer
Despite the recent influx of immunotherapies and small molecule drugs to treat tumors,
cancer remains a leading cause of death in the United States, in large part due to the …

Systems medicine for precise targeting of glioblastoma

J Zeng, XX Zeng - Molecular Biotechnology, 2023 - Springer
Glioblastoma (GBM) is a malignant cancer that is fatal even after standard therapy and the
effects of current available therapeutics are not promising due its complex and evolving …

Cytotoxic Engineered Induced Neural Stem Cells as an Intravenous Therapy for Primary Non–Small Cell Lung Cancer and Triple-Negative Breast Cancer

AR Mercer-Smith, W Jiang, JR Bago, A Valdivia… - Molecular cancer …, 2021 - AACR
Converting human fibroblasts into personalized induced neural stem cells (hiNSC) that
actively seek out tumors and deliver cytotoxic agents is a promising approach for treating …