The angiotensin-converting enzyme 2 (ACE2) is the receptor for the three coronaviruses
HCoV-NL63, SARS-CoV, and SARS-CoV-2. ACE2 is involved in the regulation of the renin …

The interplay between extrinsic signaling and downstream gene networks controls the
establishment of cell identity during development and its maintenance in adult life. Advances …

The genetic basis of human facial variation and craniofacial birth defects remains poorly
understood. Distant-acting transcriptional enhancers control the fine-tuned spatiotemporal …

Health span is driven by a precise interplay between genes and the environment. Cell
response to environmental cues is mediated by signaling cascades and genetic variants that …

Among the large number of attributes that define pork quality, fat content and composition
have attracted the attention of breeders in the recent years due to their interaction with …

The age of sequencing has provided unprecedented insights into the human genome. The
coding region of the genome comprises nearly 20,000 genes, of which approximately 4000 …

Gene regulation through DNA methylation is a well described phenomenon that has a
prominent role in physiological and pathological cell-states. This epigenetic modification is …

Epigenomics, the study of modifications to genetic material that do not alter the underlying
DNA sequence, is generating increasing interest as a means to help clarify disease …

In mammals, genomic imprinting operates via gene silencing mechanisms. Although
conservation of the imprinting mechanism at the H19/IGF2 locus has been generally …

Abstract Knowledge about transcription factor binding and regulation, target genes, cis-
regulatory modules and topologically associating domains is not only defined by functional …