A review of pharmacogenetics of antimalarials and associated clinical implications
Genetic variability in drug-metabolizing enzymes and drug transporters is known to
influence the pharmacokinetics of many drugs. Antimalarial drugs are a class of agents …
influence the pharmacokinetics of many drugs. Antimalarial drugs are a class of agents …
Cytochrome P450 pharmacogenetics in African populations
M Alessandrini, S Asfaha, TM Dodgen… - Drug metabolism …, 2013 - Taylor & Francis
Abstract The Cytochrome P450 (CYP450) family of enzymes is involved in the oxidative
metabolism of many therapeutic drugs, carcinogens and various endogenous substrates …
metabolism of many therapeutic drugs, carcinogens and various endogenous substrates …
Effect of Single Nucleotide Polymorphisms in Cytochrome P450 Isoenzyme and N-Acetyltransferase 2 Genes on the Metabolism of Artemisinin-Based Combination …
EM Staehli Hodel, C Csajka, F Ariey… - Antimicrobial agents …, 2013 - Am Soc Microbiol
The pharmacogenetics of antimalarial agents are poorly known, although the application of
pharmacogenetics might be critical in optimizing treatment. This population pharmacokinetic …
pharmacogenetics might be critical in optimizing treatment. This population pharmacokinetic …
Global pharmacogenomics: distribution of CYP3A5 polymorphisms and phenotypes in the Brazilian population
G Suarez-Kurtz, DD Vargens, AB Santoro, MH Hutz… - PLoS one, 2014 - journals.plos.org
The influence of self-reported “race/color”, geographical origin and genetic ancestry on the
distribution of three functional CYP3A5 polymorphisms, their imputed haplotypes and …
distribution of three functional CYP3A5 polymorphisms, their imputed haplotypes and …
Frequencies and roles of CYP3A5, CYP3A4 and ABCB1 single nucleotide polymorphisms in Italian teenagers after kidney transplantation
S Turolo, AS Tirelli, M Ferraresso, L Ghio… - Pharmacological …, 2010 - Springer
The main genes involved in the pharmacokinetics of immunosuppressive drugs are those
encoding cytochrome P450 (CYP) family enzymes and multidrug resistance 1 (ABCB1). In …
encoding cytochrome P450 (CYP) family enzymes and multidrug resistance 1 (ABCB1). In …
Pharmacogenetics of calcineurin inhibitors in Brazilian renal transplant patients
A Santoro, CR Felipe, H Tedesco-Silva… - …, 2011 - Taylor & Francis
Aim: Polymorphisms in the CYP3A5 and ABCB1 genes have been investigated as
modulators of the pharmacokinetics and clinical effects of cyclosporine (CSA) and tacrolimus …
modulators of the pharmacokinetics and clinical effects of cyclosporine (CSA) and tacrolimus …
Relationship of CYP3A5 genotype and ABCB1 diplotype to tacrolimus disposition in Brazilian kidney transplant patients
DAC Cusinato, R Lacchini, EA Romao… - British journal of …, 2014 - Wiley Online Library
Aims Tacrolimus (TAC) is one of the most successful immunosuppressive drugs in
transplantation. Its pharmacokinetics (PK) and pharmacogenetics (PG) have been …
transplantation. Its pharmacokinetics (PK) and pharmacogenetics (PG) have been …
An update on pharmacogenetic factors influencing the metabolism and toxicity of artemisinin-based combination therapy in the treatment of malaria
L Pernaute-Lau, M Camara… - Expert Opinion on …, 2022 - Taylor & Francis
Introduction Artemisinin-based combination therapies (ACTs) are recommended first-line
antimalarials for uncomplicated Plasmodium falciparum malaria. Pharmacokinetic …
antimalarials for uncomplicated Plasmodium falciparum malaria. Pharmacokinetic …
Genetic diversity in drug transporters: impact in African populations
I Rajman, L Knapp, I Hanna - Clinical and translational science, 2020 - Wiley Online Library
Polymorphisms in drug transporters, like the adenosine triposphate‒binding cassette (ABC)
and solute carrier (SLC) superfamilies, may contribute to the observed diversity in drug …
and solute carrier (SLC) superfamilies, may contribute to the observed diversity in drug …
[HTML][HTML] Frequencies of cytochrome P450 2B6 and 2C8 allelic variants in the Mozambican population
P Arnaldo, RE Thompson, MQ Lopes… - … Malaysian Journal of …, 2013 - ncbi.nlm.nih.gov
Background: The cytochrome P450 enzymes (CYP) play an important role in the metabolism
of many therapeutic agents. The activities of different enzymes exhibit variability in different …
of many therapeutic agents. The activities of different enzymes exhibit variability in different …