Microbiome-based therapeutics
MT Sorbara, EG Pamer - Nature Reviews Microbiology, 2022 - nature.com
Symbiotic microorganisms inhabiting the gastrointestinal tract promote health by decreasing
susceptibility to infection and enhancing resistance to a range of diseases. In this Review …
susceptibility to infection and enhancing resistance to a range of diseases. In this Review …
Bacterial defences: mechanisms, evolution and antimicrobial resistance
Throughout their evolutionary history, bacteria have faced diverse threats from other
microorganisms, including competing bacteria, bacteriophages and predators. In response …
microorganisms, including competing bacteria, bacteriophages and predators. In response …
Microbiota-mediated colonization resistance: mechanisms and regulation
G Caballero-Flores, JM Pickard, G Núñez - Nature Reviews …, 2023 - nature.com
A dense and diverse microbial community inhabits the gut and many epithelial surfaces.
Referred to as the microbiota, it co-evolved with the host and is beneficial for many host …
Referred to as the microbiota, it co-evolved with the host and is beneficial for many host …
Genetic innovations in animal–microbe symbioses
Animal hosts have initiated myriad symbiotic associations with microorganisms and often
have maintained these symbioses for millions of years, spanning drastic changes in …
have maintained these symbioses for millions of years, spanning drastic changes in …
Type VI secretion system effector proteins: effective weapons for bacterial competitiveness
RE Hernandez, R Gallegos‐Monterrosa… - Cellular …, 2020 - Wiley Online Library
The Type VI secretion system (T6SS) is a protein translocation nanomachine widespread
among Gram‐negative bacteria and used as a means to deliver effectors directly into target …
among Gram‐negative bacteria and used as a means to deliver effectors directly into target …
Activity, delivery, and diversity of Type VI secretion effectors
D Jurėnas, L Journet - Molecular Microbiology, 2021 - Wiley Online Library
The bacterial type VI secretion system (T6SS) system is a contractile secretion apparatus
that delivers proteins to neighboring bacterial or eukaryotic cells. Antibacterial effectors are …
that delivers proteins to neighboring bacterial or eukaryotic cells. Antibacterial effectors are …
The gut microbiota protects bees from invasion by a bacterial pathogen
Commensal microbes in animal guts often help to exclude bacterial pathogens. In honey
bees, perturbing or depleting the gut microbiota increases host mortality rates upon …
bees, perturbing or depleting the gut microbiota increases host mortality rates upon …
The central role of interbacterial antagonism in bacterial life
SB Peterson, SK Bertolli, JD Mougous - Current Biology, 2020 - cell.com
The study of bacteria interacting with their environment has historically centered on
strategies for obtaining nutrients and resisting abiotic stresses. We argue this focus has …
strategies for obtaining nutrients and resisting abiotic stresses. We argue this focus has …
Contact-dependent interbacterial antagonism mediated by protein secretion machines
To establish and maintain an ecological niche, bacteria employ a wide range of pathways to
inhibit the growth of their microbial competitors. Some of these pathways, such as those that …
inhibit the growth of their microbial competitors. Some of these pathways, such as those that …
Rhs NADase effectors and their immunity proteins are exchangeable mediators of inter-bacterial competition in Serratia
M Hagan, G Pankov, R Gallegos-Monterrosa… - Nature …, 2023 - nature.com
Many bacterial species use Type VI secretion systems (T6SSs) to deliver anti-bacterial
effector proteins into neighbouring bacterial cells, representing an important mechanism of …
effector proteins into neighbouring bacterial cells, representing an important mechanism of …