Erythropoiesis occurs mostly in bone marrow and ends in blood stream. Mature red blood
cells are generated from multipotent hematopoietic stem cells, through a complex maturation …

This article reviews the regulation of production of RBCs at several levels. We focus on the
regulated expansion of burst-forming unit-erythroid erythroid progenitors by glucocorticoids …

Chicken erythrocytes are nucleated cells often considered to be transcriptionally inactive,
although the epigenetic changes and chromatin remodeling that would mediate …

A characteristic feature of terminal erythropoiesis in mammals is extrusion of the highly
condensed nucleus out of the cytoplasm. Other vertebrates, including fish, reptiles …

Cancer is a multi‐faceted disease comprised of a combination of genetic, epigenetic,
metabolic and signalling aberrations which severely disrupt the normal homoeostasis of cell …

In all vertebrates, the cell nucleus becomes highly condensed and transcriptionally inactive
during the final stages of red cell biogenesis. Enucleation, the process by which the nucleus …

Hematopoietic stem and progenitor cells (HSPCs) develop in distinct waves at various
anatomical sites during embryonic development. The in vitro differentiation of human …

Using RNA-seq technology, we found that the majority of microRNAs (miRNAs) present in
CFU-E erythroid progenitors are down-regulated during terminal erythroid differentiation. Of …

Mammalian erythropoiesis involves chromatin condensation that is initiated in the early
stage of terminal differentiation. The mechanisms of chromatin condensation during …

Glucose-6-phosphate dehydrogenase (G6PD) maintains redox balance in a variety of cell
types and is essential for erythrocyte resistance to oxidative stress. G6PD deficiency, caused …