Endothelial cells (ECs) are vascular, nonconventional immune cells that play a major role in
the systemic response after bacterial infection to limit its dissemination. Triggered by …

In recent years, the traditional view of the hemostatic system as being regulated by a
coagulation factor cascade coupled with platelet activation has been increasingly …

Thrombomodulin (TM) is an integral component of a multimolecular system, localized
primarily to the vascular endothelium, that integrates crucial biological processes and …

Proteases are an expanding class of drugs that hold great promise. The US FDA (Food and
Drug Administration) has approved 12 protease therapies, and a number of next generation …

Protein C is a plasma serine protease zymogen whose active form, activated protein C
(APC), exerts potent anticoagulant activity. In addition to its antithrombotic role as a plasma …

Activated protein C (APC) is a multifunctional serine protease with anticoagulant,
cytoprotective, and anti-inflammatory activities. In addition to the cytoprotective effects of …

Plasma protein C is a serine protease zymogen that is transformed into the active, trypsin-
like protease, activated protein C (APC), which can exert multiple activities. For its …

Protein C is a vitamin K-dependent anticoagulant serine protease zymogen in plasma which
upon activation by the thrombin-thrombomodulin complex down-regulates the coagulation …

The efficient trafficking of immune cells into peripheral nonlymphoid tissues is key to enact
their protective functions. Despite considerable advances in our understanding of cell …

The thrombomodulin (TM)/activated protein C (APC) system plays an important role in
maintaining the homeostasis of thrombosis and hemostasis and maintaining vascular …