[PDF][PDF] Detect and destroy: CRISPR-based technologies for the response against viruses
CA Freije, PC Sabeti - Cell host & microbe, 2021 - cell.com
Despite numerous viral outbreaks in the last decade, including a devastating global
pandemic, diagnostic and therapeutic technologies remain severely lacking. CRISPR-Cas …
pandemic, diagnostic and therapeutic technologies remain severely lacking. CRISPR-Cas …
[HTML][HTML] Therapeutic potentials of CRISPR-Cas genome editing technology in human viral infections
Viral infections are a common cause of morbidity worldwide. The emergence of Coronavirus
Disease 2019 (COVID-19) has led to more attention to viral infections and finding novel …
Disease 2019 (COVID-19) has led to more attention to viral infections and finding novel …
[HTML][HTML] Sequential LASER ART and CRISPR treatments eliminate HIV-1 in a subset of infected humanized mice
Elimination of HIV-1 requires clearance and removal of integrated proviral DNA from
infected cells and tissues. Here, sequential long-acting slow-effective release antiviral …
infected cells and tissues. Here, sequential long-acting slow-effective release antiviral …
[HTML][HTML] CRISPR based editing of SIV proviral DNA in ART treated non-human primates
Elimination of HIV DNA from infected individuals remains a challenge in medicine. Here, we
demonstrate that intravenous inoculation of SIV-infected macaques, a well-accepted non …
demonstrate that intravenous inoculation of SIV-infected macaques, a well-accepted non …
[HTML][HTML] Off-target analysis in gene editing and applications for clinical translation of CRISPR/Cas9 in HIV-1 therapy
As genome-editing nucleases move towards broader clinical applications, the need to
define the limits of their specificity and efficiency increases. A variety of approaches for …
define the limits of their specificity and efficiency increases. A variety of approaches for …
CRISPR-Cas biology and its application to infectious diseases
JR Strich, DS Chertow - Journal of clinical microbiology, 2019 - Am Soc Microbiol
Infectious diseases remain a global threat contributing to excess morbidity and death
annually, with the persistent potential for destabilizing pandemics. Improved understanding …
annually, with the persistent potential for destabilizing pandemics. Improved understanding …
CRISPR-Cas9 system: a genome-editing tool with endless possibilities
The discovery of CRISPR: Cas9 and its application as a powerful gene-editing tool has
transformed the world of basic and applied science, especially the molecular biology dome …
transformed the world of basic and applied science, especially the molecular biology dome …
[HTML][HTML] CRISPR/Cas9: a tool to eradicate HIV-1
R Bhowmik, B Chaubey - AIDS Research and Therapy, 2022 - Springer
The development of antiretroviral therapy (ART) has been effective in suppressing HIV
replication. However, severe drug toxicities due to the therapy and its failure in targeting the …
replication. However, severe drug toxicities due to the therapy and its failure in targeting the …
[HTML][HTML] Elimination of infectious HIV DNA by CRISPR–Cas9
AT Das, CS Binda, B Berkhout - Current opinion in virology, 2019 - Elsevier
Highlights•HIV provirus in infected cells can be inactivated with CRISPR–
Cas9.•Combinatorial CRISPR–Cas9 attack can prevent viral escape.•Both mutation and …
Cas9.•Combinatorial CRISPR–Cas9 attack can prevent viral escape.•Both mutation and …
[PDF][PDF] Modulating HIV-1 envelope glycoprotein conformation to decrease the HIV-1 reservoir
Small CD4-mimetic compounds (CD4mc) sensitize HIV-1-infected cells to antibody-
dependent cellular cytotoxicity (ADCC) by facilitating antibody recognition of epitopes that …
dependent cellular cytotoxicity (ADCC) by facilitating antibody recognition of epitopes that …