Neutrophils are major effectors and regulators of the immune system. They play critical roles
not only in the eradication of pathogens but also in cancer initiation and progression …

Anatomic pathology studies performed over 150 years ago revealed that excessive
activation of coagulation occurs in the setting of inflammation. However, it has taken over a …

In recent years, the traditional view of the hemostatic system as being regulated by a
coagulation factor cascade coupled with platelet activation has been increasingly …

Blood contains microparticles (MPs) derived from a variety of cell types, including platelets,
monocytes, and endothelial cells. In addition, tumors release MPs into the circulation. MPs …

The formation of blood clots—thrombosis—at sites of atherosclerotic plaque rupture is a
major clinical problem despite ongoing improvements in antithrombotic therapy. Progress in …

Neutrophils are well known for their role in infection and inflammatory disease and are first
responders at sites of infection or injury. Platelets have an established role in hemostasis …

Mechanisms of Thrombus Formation | New England Journal of Medicine Skip to main content
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Achieving hemostasis following vascular injury requires the rapid accumulation of platelets
and fibrin. Here we used a combination of confocal intravital imaging, genetically …

Despite significant evidence implicating an important role for neutrophils in thrombosis, their
impact on the thrombotic process has remained a matter of controversy. Until 2010, platelets …

Microparticles (MPs) derived from platelets, monocytes, endothelial cells, red blood cells,
and granulocytes may be detected in low concentrations in normal plasma and at increased …