The expanding role of pyridine and dihydropyridine scaffolds in drug design

Y Ling, ZY Hao, D Liang, CL Zhang… - Drug design …, 2021 - Taylor & Francis
Pyridine-based ring systems are one of the most extensively used heterocycles in the field of
drug design, primarily due to their profound effect on pharmacological activity, which has led …

[HTML][HTML] Heterocyclic anticancer compounds: recent advances and the paradigm shift towards the use of nanomedicine's tool box

P Martins, J Jesus, S Santos, LR Raposo… - Molecules, 2015 - mdpi.com
The majority of heterocycle compounds and typically common heterocycle fragments
present in most pharmaceuticals currently marketed, alongside with their intrinsic versatility …

[HTML][HTML] Pyridine compounds with antimicrobial and antiviral activities

M Marinescu, CV Popa - International journal of molecular sciences, 2022 - mdpi.com
In the context of the new life-threatening COVID-19 pandemic caused by the SARS-CoV-2
virus, finding new antiviral and antimicrobial compounds is a priority in current research …

Insights into the structure activity relationship of nitrogen-containing heterocyclics for the development of antidepressant compounds: An updated review

K Singh, R Pal, SA Khan, B Kumar, MJ Akhtar - Journal of Molecular …, 2021 - Elsevier
Abstract According to the World Health Organization (WHO), depression is a common
mental disorder and includes complex interaction between social and psychological …

[PDF][PDF] A review on heterocyclic: Synthesis and their application in medicinal chemistry of imidazole moiety

M Hossain, AK Nanda - Science, 2018 - researchgate.net
In an organic chemistry, largest families of organic compounds are belongs in the
heterocyclic compounds. In our daily life important of heterocyclic compounds are of very …

Antiviral activities of pyridine fused and pyridine containing heterocycles, a review (from 2000 to 2020)

SR Alizadeh, MA Ebrahimzadeh - Mini Reviews in Medicinal …, 2021 - ingentaconnect.com
Heterocyclic compounds play a critical role in medicinal chemistry, and many available
drugs contain heterocyclic rings. A six-membered heterocyclic compound, pyridine, showed …

A therapeutic journey of pyridine-based heterocyclic compounds as potent anticancer agents: a review (from 2017 to 2021)

M Alrooqi, S Khan, FA Alhumaydhi… - Anti-Cancer Agents …, 2022 - ingentaconnect.com
Pyridine derivatives are the most common and significant heterocyclic compounds, which
show their fundamental characteristics to various pharmaceutical agents and natural …

Dependence on linkers' flexibility designed for benzenesulfonamides targeting discovery of novel hCA IX inhibitors as potent anticancer agents

HO Tawfik, A Belal, MAS Abourehab… - Journal of Enzyme …, 2022 - Taylor & Francis
Herein we reported the design and synthesis of two series comprising twenty-two
benzenesulfonamides that integrate the s-triazine moiety. Target compounds successfully …

A review on synthesis, reactions and biological properties of seven membered heterocyclic compounds: azepine, azepane, azepinone

M Kaur, S Garg, DS Malhi… - Current Organic Chemistry, 2021 - ingentaconnect.com
Seven membered heterocyclic Azepine and its derivatives have great pharmacological and
therapeutic implications. In this review, the literature of the last fifty years has been exploited …

Investigation of biological activity of 2, 3-disubstituted quinazolin-4 (1 H)-ones against Mycobacterium tuberculosis and DNA via docking, spectroscopy and DFT …

CBP Kumar, MS Raghu, KNN Prasad… - New Journal of …, 2021 - pubs.rsc.org
A series of 2, 3-disubstituted quinazolin-4 (1H)-ones (3a–j) were screened for their
antimicrobial activity via the minimum inhibitory concentration method (MIC). The in vitro anti …