Neurodegenerative diseases are characterised by progressive damage to the nervous
system including the selective loss of vulnerable populations of neurons leading to motor …

The ubiquitin-proteasome system (UPS) is one of the major protein degradation pathways,
where abnormal UPS function has been observed in cancer and neurological diseases …

Parkinson's disease (PD) is a common motor disorder of mysterious etiology. It is due to the
progressive degeneration of the dopaminergic neurons of the substantia nigra and is …

Ubiquitylation is a major posttranslational modification that controls most complex aspects of
cell physiology. It is reversed through the action of a large family of deubiquitylating …

Parkinson's disease (PD) is a progressive neurodegenerative movement disorder that
results primarily from the death of dopaminergic neurons in the substantia nigra. Although …

Gene defects play a major role in the pathogenesis of degenerative disorders of the nervous
system. In fact, it has been the very knowledge gained from genetic studies that has allowed …

Parkinson disease (PD) is a relatively common disorder of the nervous system that afflicts
patients later in life with tremor, slowness of movement, gait instability, and rigidity …

An increasing wealth of data indicates a close relationship between the presynaptic protein
alpha-synuclein and Parkinson's disease (PD) pathogenesis. Alpha-synuclein protein levels …

Parkinson's disease (PD) is the second most common movement disorder. The
characteristic motor impairments-bradykinesia, rigidity, and resting tremor-result from …

Parkinson disease is a complex, multifactorial neurodegenerative disease. Although a
heritable basis was originally thought unlikely, recent studies have implicated several genes …