Imaging and biophysical modelling of thrombogenic mechanisms in atrial fibrillation and stroke

A Qureshi, GYH Lip, DA Nordsletten… - Frontiers in …, 2023 - frontiersin.org
Atrial fibrillation (AF) underlies almost one third of all ischaemic strokes, with the left atrial
appendage (LAA) identified as the primary thromboembolic source. Current stroke risk …

Computational flow dynamic analysis in left atrial appendage thrombus formation risk: A review

S Valvez, M Oliveira-Santos, AP Piedade… - Applied Sciences, 2023 - mdpi.com
Atrial fibrillation (AF) is a common cardiac arrhythmia characterized by irregular and rapid
electrical activity in the atria, leading to ineffective contraction and poor blood flow. More …

Hemodynamics of the heart's left atrium based on a variational multiscale-LES numerical method

A Zingaro, F Menghini, A Quarteroni - European Journal of Mechanics-B …, 2021 - Elsevier
In this paper, we investigate the haemodynamics of a left atrium (LA) by proposing a
computational model suitable to provide physically meaningful fluid dynamics indications …

Impact of atrial fibrillation on left atrium haemodynamics: A computational fluid dynamics study

M Corti, A Zingaro, AM Quarteroni - Computers in Biology and Medicine, 2022 - Elsevier
We analyse the haemodynamics of the left atrium, highlighting differences between healthy
individuals and patients affected by atrial fibrillation. The computational study is based on …

[HTML][HTML] An electromechanics-driven fluid dynamics model for the simulation of the whole human heart

A Zingaro, M Bucelli, R Piersanti, F Regazzoni… - Journal of …, 2024 - Elsevier
We introduce a multiphysics and geometric multiscale computational model, suitable to
describe the hemodynamics of the whole human heart, driven by a four-chamber …

Sensitivity analysis of in silico fluid simulations to predict thrombus formation after left atrial appendage occlusion

J Mill, V Agudelo, AL Olivares, MI Pons, E Silva… - Mathematics, 2021 - mdpi.com
Atrial fibrillation (AF) is nowadays the most common human arrhythmia and it is considered
a marker of an increased risk of embolic stroke. It is known that 99% of AF-related thrombi …

The role of the pulmonary veins on left atrial flow patterns and thrombus formation

J Mill, J Harrison, M Saiz-Vivo, C Albors, X Morales… - Scientific Reports, 2024 - nature.com
Atrial fibrillation (AF) is the most common human arrhythmia, forming thrombi mostly in the
left atrial appendage (LAA). However, the relation between LAA morphology, blood patterns …

Regional left atrial conduction velocity in the anterior wall is associated with clinical recurrence of atrial fibrillation after catheter ablation: efficacy in combination with …

S Ohguchi, Y Inden, S Yanagisawa, R Fujita… - BMC Cardiovascular …, 2022 - Springer
Background Left atrial (LA) conduction velocity (CV) is an electrical remodeling parameter of
atrial fibrillation (AF) substrate. However, the pathophysiological substrate of LA-CV and its …

On the impact of left upper lobectomy on the left atrial hemodynamics

T Otani, T Yoshida, W Yi, S Endo, S Wada - Frontiers in Physiology, 2022 - frontiersin.org
The left atrium (LA) functions to transport oxygenated blood from the pulmonary veins (PVs)
to the left ventricle (LV). LA hemodynamics has received much attention because thrombosis …

Modelling left atrial flow and blood coagulation for risk of thrombus formation in atrial fibrillation

A Qureshi, O Darwish, D Dillon-Murphy… - 2020 Computing in …, 2020 - ieeexplore.ieee.org
Atrial fibrillation (AF) diminishes left atrial (LA) mechanical function and impairs blood flow.
The latter can lead to blood stasis and increased risk of thrombus formation and stroke. We …