MicroRNA-mediated regulation of glucose and lipid metabolism

P Agbu, RW Carthew - Nature reviews Molecular cell biology, 2021 - nature.com
In animals, systemic control of metabolism is conducted by metabolic tissues and relies on
the regulated circulation of a plethora of molecules, such as hormones and lipoprotein …

Harnessing genomic information for livestock improvement

M Georges, C Charlier, B Hayes - Nature Reviews Genetics, 2019 - nature.com
The world demand for animal-based food products is anticipated to increase by 70% by
2050. Meeting this demand in a way that has a minimal impact on the environment will …

SIFT missense predictions for genomes

R Vaser, S Adusumalli, SN Leng, M Sikic, PC Ng - Nature protocols, 2016 - nature.com
The SIFT (sorting intolerant from tolerant) algorithm helps bridge the gap between mutations
and phenotypic variations by predicting whether an amino acid substitution is deleterious …

1000 bull genomes project to map simple and complex genetic traits in cattle: applications and outcomes

BJ Hayes, HD Daetwyler - Annual review of animal biosciences, 2019 - annualreviews.org
The 1000 Bull Genomes Project is a collection of whole-genome sequences from 2,703
individuals capturing a significant proportion of the world's cattle diversity. So far, 84 million …

Whole-genome resequencing reveals world-wide ancestry and adaptive introgression events of domesticated cattle in East Asia

N Chen, Y Cai, Q Chen, R Li, K Wang, Y Huang… - Nature …, 2018 - nature.com
Cattle domestication and the complex histories of East Asian cattle breeds warrant further
investigation. Through analysing the genomes of 49 modern breeds and eight East Asian …

Whole-genome sequencing of 234 bulls facilitates mapping of monogenic and complex traits in cattle

HD Daetwyler, A Capitan, H Pausch, P Stothard… - Nature …, 2014 - nature.com
The 1000 bull genomes project supports the goal of accelerating the rates of genetic gain in
domestic cattle while at the same time considering animal health and welfare by providing …

LinkImpute: fast and accurate genotype imputation for nonmodel organisms

D Money, K Gardner, Z Migicovsky… - G3: Genes …, 2015 - academic.oup.com
Obtaining genome-wide genotype data from a set of individuals is the first step in many
genomic studies, including genome-wide association and genomic selection. All genotyping …

Genomic selection in dairy cattle: the USDA experience

GR Wiggans, JB Cole, SM Hubbard… - Annual review of …, 2017 - annualreviews.org
Genomic selection has revolutionized dairy cattle breeding. Since 2000, assays have been
developed to genotype large numbers of single-nucleotide polymorphisms (SNPs) at …

Genome-wide analysis of the world's sheep breeds reveals high levels of historic mixture and strong recent selection

JW Kijas, JA Lenstra, B Hayes, S Boitard… - PLoS …, 2012 - journals.plos.org
Through their domestication and subsequent selection, sheep have been adapted to thrive
in a diverse range of environments. To characterise the genetic consequence of both …

Resequencing 50 accessions of cultivated and wild rice yields markers for identifying agronomically important genes

X Xu, X Liu, S Ge, JD Jensen, F Hu, X Li, Y Dong… - Nature …, 2012 - nature.com
Rice is a staple crop that has undergone substantial phenotypic and physiological changes
during domestication. Here we resequenced the genomes of 40 cultivated accessions …