Ketamine, a non-competitive antagonist of N-methyl-D-aspartate (NMDA) receptor, displays
a fast antidepressant activity in treatment-resistant depression and in rodent models of …

The intestinal microbiota plays an important role in the pathophysiology of depression. As
determined, the microbiota influences the shaping and modulation of the functioning of the …

Anxiety disorders are the most prevalent group of psychiatric diseases, and have high
personal and societal costs. The search for novel pharmacological treatments for these …

The medial prefrontal cortex (mPFC) and ventral hippocampus (vHPC) functionally interact
during innate anxiety tasks. To explore the consequences of this interaction, we examined …

In recent years, both major depression and antidepressant therapy have been linked to adult
hippocampal neurogenesis. The hippocampus is not a homogeneous brain area, and a …

Preclinical and some clinical studies suggest a relationship between perturbation in
magnesium (Mg2+) homeostasis and pathological anxiety, although the underlying …

Background Resistance to antidepressant drug treatment remains a major health problem.
Animal models of depression are efficient in detecting effective treatments but have done …

Identifying the factors contributing to the etiology of anxiety and depression is critical for the
development of more efficacious therapies. Serotonin (5-HT) is intimately linked to both …

Vortioxetine (Lu AA21004) is an investigational novel antidepressant with multimodal activity
that functions as a 5-HT 3, 5-HT 7 and 5-HT 1D receptor antagonist, 5-HT 1B receptor partial …

Background The postnatal period is a critical time window during which inflammatory events
have significant and enduring effects on the brain, and as a consequence, induce alterations …