[HTML][HTML] Pattern recognition receptors in health and diseases
D Li, M Wu - Signal transduction and targeted therapy, 2021 - nature.com
Pattern recognition receptors (PRRs) are a class of receptors that can directly recognize the
specific molecular structures on the surface of pathogens, apoptotic host cells, and damaged …
specific molecular structures on the surface of pathogens, apoptotic host cells, and damaged …
Smart contact lenses as wearable ophthalmic devices for disease monitoring and health management
The eye contains a complex network of physiological information and biomarkers for
monitoring disease and managing health, and ocular devices can be used to effectively …
monitoring disease and managing health, and ocular devices can be used to effectively …
[HTML][HTML] Phages and their satellites encode hotspots of antiviral systems
Bacteria carry diverse genetic systems to defend against viral infection, some of which are
found within prophages where they inhibit competing viruses. Phage satellites pose …
found within prophages where they inhibit competing viruses. Phage satellites pose …
[HTML][HTML] Painful intervertebral disc degeneration and inflammation: from laboratory evidence to clinical interventions
Low back pain (LBP), as a leading cause of disability, is a common musculoskeletal disorder
that results in major social and economic burdens. Recent research has identified …
that results in major social and economic burdens. Recent research has identified …
[HTML][HTML] Role of metabolic endotoxemia in systemic inflammation and potential interventions
S Mohammad, C Thiemermann - Frontiers in immunology, 2021 - frontiersin.org
Diet-induced metabolic endotoxemia is an important factor in the development of many
chronic diseases in animals and man. The gut epithelium is an efficient barrier that prevents …
chronic diseases in animals and man. The gut epithelium is an efficient barrier that prevents …
[HTML][HTML] Pyroptosis: A new frontier in cancer
Y Fang, S Tian, Y Pan, W Li, Q Wang, Y Tang… - Biomedicine & …, 2020 - Elsevier
Pyroptosis is an inflammatory form of cell death triggered by certain inflammasomes, leading
to the cleavage of gasdermin D (GSDMD) and activation of inactive cytokines like IL-18 and …
to the cleavage of gasdermin D (GSDMD) and activation of inactive cytokines like IL-18 and …
Polymeric delivery of therapeutic nucleic acids
R Kumar, CF Santa Chalarca, MR Bockman… - Chemical …, 2021 - ACS Publications
The advent of genome editing has transformed the therapeutic landscape for several
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …
[HTML][HTML] Major pathways involved in macrophage polarization in cancer
C Kerneur, CE Cano, D Olive - Frontiers in immunology, 2022 - frontiersin.org
Macrophages play an important role in tissue homeostasis, tissue remodeling, immune
response, and progression of cancer. Consequently, macrophages exhibit significant …
response, and progression of cancer. Consequently, macrophages exhibit significant …
Phagocytosis checkpoints as new targets for cancer immunotherapy
Cancer immunotherapies targeting adaptive immune checkpoints have substantially
improved patient outcomes across multiple metastatic and treatment-refractory cancer types …
improved patient outcomes across multiple metastatic and treatment-refractory cancer types …
[HTML][HTML] CNS remyelination and inflammation: From basic mechanisms to therapeutic opportunities
RJM Franklin, M Simons - Neuron, 2022 - cell.com
Remyelination, the myelin regenerative response that follows demyelination, restores
saltatory conduction and function and sustains axon health. Its declining efficiency with …
saltatory conduction and function and sustains axon health. Its declining efficiency with …