Spatial metabolomics and imaging mass spectrometry in the age of artificial intelligence
T Alexandrov - Annual review of biomedical data science, 2020 - annualreviews.org
Spatial metabolomics is an emerging field of omics research that has enabled localizing
metabolites, lipids, and drugs in tissue sections, a feat considered impossible just two …
metabolites, lipids, and drugs in tissue sections, a feat considered impossible just two …
Desorption electrospray ionization mass spectrometry imaging in discovery and development of novel therapies
T Soudah, A Zoabi, K Margulis - Mass Spectrometry Reviews, 2023 - Wiley Online Library
Desorption electrospray ionization mass spectrometry imaging (DESI‐MSI) is one of the
least specimen destructive ambient ionization mass spectrometry tissue imaging methods. It …
least specimen destructive ambient ionization mass spectrometry tissue imaging methods. It …
Considerations for MALDI-based quantitative mass spectrometry imaging studies
F Tobias, AB Hummon - Journal of proteome research, 2020 - ACS Publications
Significant advances in mass spectrometry imaging (MSI) have pushed the boundaries in
obtaining spatial information and quantification in biological samples. Quantitative MSI …
obtaining spatial information and quantification in biological samples. Quantitative MSI …
Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target
J Vande Voorde, RT Steven, AK Najumudeen… - Nature …, 2023 - nature.com
The genomic landscape of colorectal cancer (CRC) is shaped by inactivating mutations in
tumour suppressors such as APC, and oncogenic mutations such as mutant KRAS. Here we …
tumour suppressors such as APC, and oncogenic mutations such as mutant KRAS. Here we …
Universal sample preparation unlocking multimodal molecular tissue imaging
A new tissue sample embedding and processing method is presented that provides
downstream compatibility with numerous different histological, molecular biology, and …
downstream compatibility with numerous different histological, molecular biology, and …
Today's challenges to de-risk and predict drug safety in human “mind-the-gap”
RJ Weaver, JP Valentin - Toxicological Sciences, 2019 - academic.oup.com
Current gaps in drug safety sciences can result from the inability (1) to identify hazard across
multiple target organs,(2) to predict and risk assess with certainty against drug safety …
multiple target organs,(2) to predict and risk assess with certainty against drug safety …
A critical and concise review of mass spectrometry applied to imaging in drug discovery
RJA Goodwin, Z Takats… - … : Advancing the Science of …, 2020 - journals.sagepub.com
During the past decade, mass spectrometry imaging (MSI) has become a robust and
versatile methodology to support modern pharmaceutical research and development. The …
versatile methodology to support modern pharmaceutical research and development. The …
Characterization of an aggregated three-dimensional cell culture model by multimodal mass spectrometry imaging
Mass spectrometry imaging (MSI) is an established analytical tool capable of defining and
understanding complex tissues by determining the spatial distribution of biological …
understanding complex tissues by determining the spatial distribution of biological …
Quantitative mass spectrometry imaging of drugs and metabolites: a multiplatform comparison
L Lamont, D Hadavi, B Viehmann, B Flinders… - Analytical and …, 2021 - Springer
Mass spectrometry imaging (MSI) provides insight into the molecular distribution of a broad
range of compounds and, therefore, is frequently applied in the pharmaceutical industry …
range of compounds and, therefore, is frequently applied in the pharmaceutical industry …
[HTML][HTML] A temporo-spatial pharmacometabolomics method to characterize pharmacokinetics and pharmacodynamics in the brain microregions by using ambient …
D Liu, J Huang, S Gao, H Jin, J He - Acta Pharmaceutica Sinica B, 2022 - Elsevier
The brain is the most advanced organ with various complex structural and functional
microregions. It is often challenging to understand what and where the molecular events …
microregions. It is often challenging to understand what and where the molecular events …