Thousands of unique non-coding RNA (ncRNA) sequences exist within cells. Work from the
past decade has altered our perception of ncRNAs from'junk'transcriptional products to …

Receptor tyrosine kinases (RTKs) play an important role in a variety of cellular processes
including growth, motility, differentiation, and metabolism. As such, dysregulation of RTK …

Chromosomal translocations encode oncogenic fusion proteins that have been proven to be
causally involved in tumorigenesis. Our understanding of whether such genomic alterations …

Background Non–small-cell lung cancer (NSCLC) harboring the anaplastic lymphoma
kinase gene (ALK) rearrangement is sensitive to the ALK inhibitor crizotinib, but resistance …

Lung cancer is the leading cause of death for malignancy worldwide. Its molecular profiling
has enriched our understanding of cancer initiation and progression and has become …

A new type of RNAs was identified from genes traditionally thought to express messenger or
linear ncRNA (noncoding RNA) only. They were subsequently named as circRNAs (circular …

Purpose: Patients with anaplastic lymphoma kinase (ALK) gene rearrangements often
manifest dramatic responses to crizotinib, a small-molecule ALK inhibitor. Unfortunately, not …

Purpose: Anaplastic lymphoma kinase (ALK) gene rearrangements define a distinct
molecular subset of non–small cell lung cancer (NSCLC). Recently, several case reports …

Deep understanding of the genomic and immunological differences between Chinese and
Western lung cancer patients is of great importance for target therapy selection and …

Lung cancer is the leading cause of cancer-related mortality. While the majority of lung
cancers are associated with tobacco smoke, approximately 10–15% of US lung cancers …