Cells differentiate and progress through development guided by a dynamic chromatin
landscape that mediates gene expression programmes. During development, mammalian …

The dynamic regulation of transcription elongation by RNA polymerase II (Pol II) is an
integral part of the implementation of gene expression programmes during development. In …

Drastic epigenetic reprogramming takes place during preimplantation development, leading
to the conversion of terminally differentiated gametes to a totipotent embryo. Deficiencies in …

Background: The angiogenic function of endothelial cells is regulated by numerous
mechanisms, but the impact of long noncoding RNAs (lncRNAs) has hardly been studied …

The precise regulation of gene transcription is required to establish and maintain cell type-
specific gene expression programs during multicellular development. In addition to …

Epigenetic mechanisms contribute to the initiation and development of cancer, and
epigenetic variation promotes dynamic gene expression patterns that facilitate tumor …

Histone methylation plays fundamental roles in regulating chromatin‐based processes. With
the discovery of histone demethylases over a decade ago, it is now clear that histone …

Mesenchymal stem cells (mesenchymal stromal cells, MSC) are multipotent stem cells that
can differentiate into cells of at least three mesodermal lineages, namely adipocytes …

Methylation of histone H3 lysine 4 (H3K4me) is an intricately regulated posttranslational
modification, which is broadly associated with enhancers and promoters of actively …

Background DNA methylation at promoters is largely correlated with inhibition of gene
expression. However, the role of DNA methylation at enhancers is not fully understood …