Over the past 20 years, there has been considerable progress in our understanding of the
biological functions of the BRCA1 and BRCA2 cancer susceptibility genes. This has led to …

Ewing's Sarcoma Ewing's sarcoma, an aggressive cancer of bone and soft tissue, primarily
affects children and young adults. A t (11; 22) translocation is noted in 85 to 90% of cases …

Background Niraparib, an inhibitor of poly (adenosine diphosphate [ADP]–ribose)
polymerase (PARP), has been associated with significantly increased progression-free …

Most human epithelial tumors harbor numerous alterations, making it difficult to predict
which genes are required for tumor survival. To systematically identify cancer dependencies …

The analysis of exonic DNA from prostate cancers has identified recurrently mutated genes,
but the spectrum of genome-wide alterations has not been profiled extensively in this …

Clinical responses to anticancer therapies are often restricted to a subset of patients. In
some cases, mutated cancer genes are potent biomarkers for responses to targeted agents …

Genomic instability is one of the most pervasive characteristics of tumour cells and is
probably the combined effect of DNA damage, tumour-specific DNA repair defects, and a …

Dysregulation of DNA damage repair and signalling to cell cycle checkpoints, known as the
DNA damage response (DDR), is associated with a predisposition to cancer and affects …

Findings over the past decade have identified aberrant activation of the ETS transcription
factor family throughout all stages of tumorigenesis. Specifically in solid tumours, gene …

Cancers with loss-of-function mutations in BRCA1 or BRCA2 are deficient in the DNA
damage repair pathway called homologous recombination (HR), rendering these cancers …