… Because nicotine and tobacco-specific nitrosamines … activating nicotinic acetylcholine
receptors (nAChRs) on lung tumors … of nAChR subunit genes in paired tumor and non-tumor lung …

… lung carcinoma; other risks include genetic factors and exposure to radon gas, asbestos,
secondhand smoke, and air pollution. Nicotine, … 5 nicotinic acetylcholine receptor subunit gene …

… A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes
… cell lung cancer in response to nicotinic acetylcholine receptor and epidermal growth factor …

… -15q25.1 and susceptibility to lung cancer (11–18). There are three nicotine acetylcholine
receptor (CHRNA) genes at this locus. Studies from the International Agency for Research on …

… showing that nicotinic receptor subtypes are involved in lung cancer risk, the relationship
between cigarette smoke and lung cancer risk as well … nAChR Nicotinic acetylcholine receptors …

… We next measured genome-wide gene expression levels in lung tissues of 409 lung cancer
patients and mapped eQTLs to determine which genes can be transcriptionally regulated by …

… A 3-Mb map of a large segmental duplication overlapping the alpha 7nicotinic acetylcholine
receptor gene (CHRNA7) at human 15q13q14. Genomics 2002; 79(2): 197-209. [77] Locke …

… Genes differentially expressed between A549 lung cancer cells transfected with α5-nAChR-specific
siRNA compared with cells transfected with scrambled siRNA were selected on the …

… susceptibility to lung cancer development. Furthermore, the gene cluster encoding the α5,
α3, and β4 nAChR subunits plays … PKC/IP3 signaling as well as the MAP/ERK, p38, and JNK …

… We mapped eSNPs to a gene if they were associated with expression levels of that … lung
cancer susceptibility genes.5 CHRNA5 encodes a nicotinic acetylcholine receptor subunit and …