Ceramides in metabolism: key lipotoxic players
B Chaurasia, SA Summers - Annual review of physiology, 2021 - annualreviews.org
The global prevalence of metabolic diseases such as type 2 diabetes mellitus,
steatohepatitis, myocardial infarction, and stroke has increased dramatically over the past …
steatohepatitis, myocardial infarction, and stroke has increased dramatically over the past …
Neurological consequences of obesity
PD O'Brien, LM Hinder, BC Callaghan… - The Lancet …, 2017 - thelancet.com
The high prevalence of obesity is associated with an enormous medical, social, and
economic burden. The metabolic dysfunction, dyslipidaemia, and inflammation caused by …
economic burden. The metabolic dysfunction, dyslipidaemia, and inflammation caused by …
[HTML][HTML] Estrogen as a key regulator of energy homeostasis and metabolic health
F Mahboobifard, MH Pourgholami, M Jorjani… - Biomedicine & …, 2022 - Elsevier
Over the last two decades, it has become evident that estrogens preserve the integrity of
energy homeostasis at central and peripheral levels. Estrogen deficiency, such as that …
energy homeostasis at central and peripheral levels. Estrogen deficiency, such as that …
The cellular and molecular bases of leptin and ghrelin resistance in obesity
Obesity, a major risk factor for the development of diabetes mellitus, cardiovascular diseases
and certain types of cancer, arises from a chronic positive energy balance that is often due to …
and certain types of cancer, arises from a chronic positive energy balance that is often due to …
Ceramides–lipotoxic inducers of metabolic disorders
B Chaurasia, SA Summers - Trends in Endocrinology & Metabolism, 2015 - cell.com
In obesity and dyslipidemia, the oversupply of fat to tissues not suited for lipid storage
induces cellular dysfunction that underlies diabetes and cardiovascular disease (ie …
induces cellular dysfunction that underlies diabetes and cardiovascular disease (ie …
[HTML][HTML] Lipid signaling and lipotoxicity in metaflammation: indications for metabolic disease pathogenesis and treatment
ME Ertunc, GS Hotamisligil - Journal of lipid research, 2016 - ASBMB
Lipids encompass a wide variety of molecules such as fatty acids, sterols, phospholipids,
and triglycerides. These molecules represent a highly efficient energy resource and can act …
and triglycerides. These molecules represent a highly efficient energy resource and can act …
Molecular Events Linking Oxidative Stress and Inflammation to Insulin Resistance and β‐Cell Dysfunction
The prevalence of diabetes mellitus (DM) is increasing worldwide, a consequence of the
alarming rise in obesity and metabolic syndrome (MetS). Oxidative stress and inflammation …
alarming rise in obesity and metabolic syndrome (MetS). Oxidative stress and inflammation …
[HTML][HTML] Role of c-Jun N-terminal kinase (JNK) in obesity and type 2 diabetes
JHM Yung, A Giacca - Cells, 2020 - mdpi.com
Obesity has been described as a global epidemic and is a low-grade chronic inflammatory
disease that arises as a consequence of energy imbalance. Obesity increases the risk of …
disease that arises as a consequence of energy imbalance. Obesity increases the risk of …
[HTML][HTML] Contribution of specific ceramides to obesity-associated metabolic diseases
P Hammerschmidt, JC Brüning - Cellular and Molecular Life Sciences, 2022 - Springer
Ceramides are a heterogeneous group of bioactive membrane sphingolipids that play
specialized regulatory roles in cellular metabolism depending on their characteristic fatty …
specialized regulatory roles in cellular metabolism depending on their characteristic fatty …
[HTML][HTML] There and back again: leptin actions in white adipose tissue
N Martínez-Sánchez - International journal of molecular sciences, 2020 - mdpi.com
Leptin is a hormone discovered almost 30 years ago with important implications in
metabolism. It is primarily produced by white adipose tissue (WAT) in proportion to the …
metabolism. It is primarily produced by white adipose tissue (WAT) in proportion to the …