The non-canonical NF-κB pathway is an important arm of NF-κB signaling that
predominantly targets activation of the p52/RelB NF-κB complex. This pathway depends on …

The noncanonical nuclear factor‐κB (NF‐κB) signaling pathway mediates activation of the
p52/RelB NF‐κB complex and, thereby, regulates specific immunological processes. This …

Gouty arthritis is a very familiar inflammatory arthritis. Controlling inflammation is the key to
preventing gouty arthritis. However, colchicine, the most highly represented drug used in …

The mammalian Rel/NF-κB family of transcription factors, including RelA, c-Rel, RelB, NF-
κB1 (p50 and its precursor p105), and NF-κB2 (p52 and its precursor p100), plays a central …

Convincing concepts of redox control of gene transcription have been worked out for
prokaryotes and lower eukaryotes, whereas the knowledge on complex mammalian systems …

Nuclear factor (NF)-κB transcription factors are pivotal regulators of innate and adaptive
immune responses, and perturbations of NF-κB signaling contribute to the pathogenesis of …

The combination of immune checkpoint blockade with chemotherapy is currently under
investigation as a promising strategy for the treatment of triple negative breast cancer …

Both melatonin and proteasome inhibitors upregulate antioxidant enzymes including
superoxide dismutase (SOD), glutathione peroxidase (GP), hemoxygenase 1 (HO-1), and …

Activation of NF-κB transcription factors by receptors of the innate or adaptive immune
system is essential for host defense. However, after danger is eliminated, NF-κB signaling …

The nuclear factor-kappa B (NF-κB) transcription factor plays a critical role in diverse cellular
processes associated with proliferation, cell death, development, as well as innate and …