Chronic liver diseases often result in the development of liver fibrosis and ultimately,
cirrhosis. Treatment strategies and prognosis differ greatly depending on the severity of liver …

Fibrosis is a pathologic process characterized by the replacement of parenchymal tissue by
large amounts of extracellular matrix, which may lead to organ dysfunction and even death …

Cell death and inflammation are two central elements in the development of liver fibrosis.
Inflammasomes are intracellular multiprotein complexes expressed in both hepatocytes and …

The NLR family pyrin domain‐containing 3 (NLRP3) inflammasome plays an important role
in liver fibrosis (LF) development. However, the mechanisms involved in NLRP3‐induced …

Liver fibrosis is part of the wound-healing response to liver damage of various origins and
represents a major health problem. Although our understanding of the pathogenesis of liver …

Liver fibrosis is a pathological wound-healing response caused by chronic liver damage due
to a virus, autoimmune disorder, or drugs. Hepatic stellate cells (HSCs) play an essential …

Cancer remains the leading cause of death around the world. In cancer treatment, over 50%
of cancer patients receive radiotherapy alone or in multimodal combinations with other …

Bacterial translocation and lipopolysaccharide (LPS) leakage occur at a very early stage of
liver fibrosis in animal models. We studied the role of LPS in hepatic stellate cell (HSC) …

Obesity and metabolic syndrome pose significant risk for the progression of many types of
chronic illness, including liver disease. Hormones released from adipocytes, adipocytokines …

Non-alcoholic fatty liver disease (NAFLD) is a common clinical disease, and its
pathogenesis is closely linked to oxidative stress and gut microbiota dysbiosis. Recently …