Growing evidence suggests that the gut microbiota modulates the efficacy and toxicity of
cancer therapy, most notably immunotherapy and its immune-related adverse effects. The …

Cytotoxic CD8+ T cells play a key role in the elimination of intracellular infections and
malignant cells and can provide long-term protective immunity. In the response to infection …

The mammalian immune system implements a remarkably effective set of mechanisms for
fighting pathogens. Its main components are haematopoietic immune cells, including …

How environmental nutrient availability impacts T cell metabolism and function remains
poorly understood. Here, we report that the presence of physiologic carbon sources (PCSs) …

Immune cells' metabolism influences their differentiation and function. Given that a complex
interplay of environmental factors within the tumor microenvironment (TME) can have a …

Diverse inflammatory diseases, infections and malignancies are associated with wasting
syndromes. In many of these conditions, the standards for diagnosis and treatment are …

Environmental nutrient availability influences T cell metabolism, impacting T cell function
and shaping immune outcomes. Here, we identified ketone bodies (KBs)—including β …

Metabolic adaptation to viral infections critically determines the course and manifestations of
disease. At the systemic level, a significant feature of viral infection and inflammation that …

Early detection and effective treatment of severe COVID-19 patients remain major
challenges. Here, we performed proteomic and metabolomic profiling of sera from 46 COVID …

The current pandemic of coronavirus disease 2019 (COVID-19) has affected> 160 million
individuals to date, and has caused millions of deaths worldwide, at least in part due to the …