Role of amino acid metabolism in mitochondrial homeostasis

Q Li, T Hoppe - Frontiers in Cell and Developmental Biology, 2023 - frontiersin.org
Mitochondria are central hubs for energy production, metabolism and cellular signal
transduction in eukaryotic cells. Maintenance of mitochondrial homeostasis is important for …

Let's get physical: flavivirus-host protein–protein interactions in replication and pathogenesis

AT Fishburn, OH Pham, MW Kenaston… - Frontiers in …, 2022 - frontiersin.org
Flaviviruses comprise a genus of viruses that pose a significant burden on human health
worldwide. Transmission by both mosquito and tick vectors, and broad host tropism …

[HTML][HTML] Epilepsy: Mitochondrial connections to the 'Sacred'disease

WH Moos, DV Faller, IP Glavas, I Kanara, K Kodukula… - Mitochondrion, 2023 - Elsevier
Over 65 million people suffer from recurrent, unprovoked seizures. The lack of validated
biomarkers specific for myriad forms of epilepsy makes diagnosis challenging. Diagnosis …

Mitochondria as the essence of Yang Qi in the human body

J Luo, S Shen, J Xia, J Wang, Z Gu - Phenomics, 2022 - Springer
Abstract The concept of Yang Qi in Traditional Chinese Medicine (TCM) has many
similarities with mitochondria in modern medicine. Both are indispensable to human beings …

High-content high-throughput imaging reveals distinct connections between mitochondrial morphology and functionality for OXPHOS complex I, III, and V inhibitors

W van der Stel, H Yang, SE le Dévédec… - Cell Biology and …, 2023 - Springer
Cells can adjust their mitochondrial morphology by altering the balance between
mitochondrial fission and fusion to adapt to stressful conditions. The connection between a …

Disease-associated genetic variation in human mitochondrial protein import

E Nicolas, R Tricarico, M Savage, EA Golemis… - The American Journal of …, 2019 - cell.com
Mitochondrial dysfunction has consequences not only for cellular energy output but also for
cellular signaling pathways. Mitochondrial dysfunction, often based on inherited gene …

Mitochondrial genetic background may impact statins side effects and atherosclerosis development in familial hypercholesterolemia

E Ruiz-Pesini, MP Bayona-Bafaluy… - International Journal of …, 2022 - mdpi.com
Heredity of familial hypercholesterolemia (FH) can present as a dominant monogenic
disorder of polygenic origin or with no known genetic cause. In addition, the variability of the …

Mitochondrial function and gastrointestinal diseases

PS Haque, N Kapur, TA Barrett, AL Theiss - Nature Reviews …, 2024 - nature.com
Mitochondria are dynamic organelles that function in cellular energy metabolism,
intracellular and extracellular signalling, cellular fate and stress responses. Mitochondria of …

[HTML][HTML] Viable allogeneic mitochondria transplantation improves gas exchange and alveolar-capillary permeability in rats with endotoxin-induced acute lung injuries

YL Pang, SY Fang, TT Cheng, CC Huang… - … Journal of Medical …, 2022 - ncbi.nlm.nih.gov
Background: Acute lung injuries (ALI) cause disruption of the alveolar-capillary barrier and is
the leading cause of death in critically ill patients. This study tested the hypothesis that the …

Peanut Shell Extract Improves Mitochondrial Function in db/db Mice via Suppression of Oxidative Stress and Inflammation

H Deshmukh, JM Santos, M Bender, JM Dufour… - Nutrients, 2024 - mdpi.com
Accumulating evidence shows a strong correlation between type 2 diabetes mellitus,
mitochondrial dysfunction, and oxidative stress. We evaluated the effects of dietary peanut …