Cancer is a leading cause of death worldwide and, despite new targeted therapies and
immunotherapies, many patients with advanced-stage-or high-risk cancers still die, owing to …

Cancer is a clonal disorder derived from a single ancestor cell and its progenies that are
positively selected by acquisition of 'driver mutations'. However, the evolution of positively …

Recent technological advances have enabled massively parallel chromatin profiling with
scATAC-seq (single-cell assay for transposase accessible chromatin by sequencing). Here …

Mutation accumulation in somatic cells contributes to cancer development and is proposed
as a cause of aging. DNA polymerases Pol ε and Pol δ replicate DNA during cell division …

RNA abundance is a powerful indicator of the state of individual cells. Single-cell RNA
sequencing can reveal RNA abundance with high quantitative accuracy, sensitivity and …

Glioblastoma (GBM) is a devastating and incurable brain tumour, with a median overall
survival of fifteen months,. Identifying the cell of origin that harbours mutations that drive …

Placentas can exhibit chromosomal aberrations that are absent from the fetus. The basis of
this genetic segregation, which is known as confined placental mosaicism, remains …

Haematopoietic stem cells drive blood production, but their population size and lifetime
dynamics have not been quantified directly in humans. Here we identified 129,582 …

The origin of human metaplastic states and their propensity for cancer is poorly understood.
Barrett's esophagus is a common metaplastic condition that increases the risk for …

Starting from the zygote, all cells in the human body continuously acquire mutations.
Mutations shared between different cells imply a common progenitor and are thus naturally …