▪ Abstract Focal adhesions are sites of tight adhesion to the underlying extracellular matrix
developed by cells in culture. They provide a structural link between the actin cytoskeleton …

The actin cytoskeleton is a complex structure that performs a wide range of cellular
functions. In 2001, significant advances were made to our understanding of the structure and …

Rho small GTPase regulates cell morphology, adhesion and cytokinesis through the actin
cytoskeleton. We have identified a protein, p140mDia, as a downstream effector of Rho. It is …

We identified four polypeptides of 47, 44, 40, and 35 kD that bind to profilin-Sepharose and
elute with high salt. When purified by conventional chromatography using an antibody to the …

The sprouting of neurites, which will later become axons and dendrites, is an important
event in early neuronal differentiation. Studies in living neurons indicate that neuritogenesis …

Proteins at the boundary between the cytoskeleton and the plasma membrane control cell
shape, delimit specialized membrane domains, and stabilize attachments to other cells and …

Cells precisely control the formation of dynamic actin cytoskeleton networks to coordinate
fundamental processes, including motility, division, endocytosis and polarization. To support …

Actin polymerization plays a major role in cell movement. The controls of actin sequestration/
desequestration and of filament turnover are two important features of cell motility. Actin …

Profilins are small proteins that form complexes with G‐actin and phosphoinositides and are
therefore considered to link the microfilament system to signal transduction pathways. In …

Cancer progression to the invasive and metastatic stage represents the most formidable
barrier to successful treatment. To develop rational therapies, we must determine the …