Systemic sclerosis (SSc) is an autoimmune, multi-organ, connective tissue disease
associated with significant morbidity and mortality. Conventional immunosuppressive …

Systemic sclerosis (SSc) is a chronic autoimmune disease that includes fibrosis, diffuse
vasculopathy, inflammation, and autoimmunity. Autologous hematopoietic stem cell …

Background Autologous hematopoietic stem cell transplantation (AHSCT) treats patients
with severe and progressive systemic sclerosis (SSc). However, basic mechanisms …

In systemic sclerosis (SSc, or scleroderma), defective angiogenesis, clinically manifesting
with abnormal capillary architecture and severe capillary reduction, represents a hallmark of …

Autoimmune diseases (ADs) are a collection of immunological disorders in which the
immune system responds to self-antigens by producing autoantibodies or self-sensitized …

Nailfold capillaroscopy (NFC) is a simple noninvasive microscopic technique used to identify
characteristic morphological abnormalities in the nailfold capillaries. The presence of this …

Objective Haematopoietic stem cell transplantation (HSCT) is a treatment option for patients
with severe systemic sclerosis (SSc), but the efficacy of the procedure in remodelling the …

Since the start of the international stem cell programme for autoimmune diseases in 1997,
3855 stem cell transplants for autoimmune disease have been registered at the European …

Microvascular remodeling and capillary repopulation can occur after autologous
hematopoietic stem cell transplant (HSCT) in patients with systemic sclerosis and systemic …

Objective To investigate the evolution of nailfold capillary density in patients with SSc in
relation to immunosuppressive treatment and autoantibodies. Methods This was a …