Proinflammatory conditions, including acute and chronic infections, have been associated
with an increased risk of stroke. The risk of stroke is increased by both the acute and chronic …

Figure 2. Regulation of the Rho GTPase cycle. Rho protein cycle between an inactive GDP-
bound and an active GTP-bound state. Inhibition of the mevalonate synthesis by statins …

Chronic inflammation is a key feature of vascular disease states such as atherosclerosis.
Multiple clinical studies have shown that a class of medications termed statins lower …

Background The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular'reactive oxygen species'(ROSs) can exhibit a …

According to traditional thinking, atherosclerosis results from passive lipid deposition in the
vascular wall. Thus, therapies predominantly targeted lipid metabolism. The contemporary …

Statins are 3-hydroxy-3-methyglutaryl coenzyme A (HMG-CoA) reductase inhibitors, which
are prescribed extensively for cholesterol lowering in the primary and secondary prevention …

Assisted reproductive technologies (ART) are associated with several complications
including low birth weight, abnormal placentation and increased risk for rare imprinting …

Rationale: In cigarette smoking–induced chronic obstructive pulmonary disease, structural
and functional derangements are characterized by parenchymal destruction and pulmonary …

The underlying cause of major cardiovascular events, such as myocardial infarctions and
strokes, is atherosclerosis. For accurate diagnosis of this inflammatory disease, molecular …

Statins reduce cholesterol synthesis and are widely used for the treatment of
hyperlipidaemia and ischaemic heart disease. Besides their cholesterol-lowering effects …