Thrombocytopenia in dengue: interrelationship between virus and the imbalance between coagulation and fibrinolysis and inflammatory mediators
EL Azeredo, RQ Monteiro… - Mediators of …, 2015 - Wiley Online Library
Dengue is an infectious disease caused by dengue virus (DENV). In general, dengue is a
self‐limiting acute febrile illness followed by a phase of critical defervescence, in which …
self‐limiting acute febrile illness followed by a phase of critical defervescence, in which …
The flavivirus NS2B–NS3 protease–helicase as a target for antiviral drug development
The flavivirus NS3 protein is associated with the endoplasmic reticulum membrane via its
close interaction with the central hydrophilic region of the NS2B integral membrane protein …
close interaction with the central hydrophilic region of the NS2B integral membrane protein …
Phototactic guidance of a tissue-engineered soft-robotic ray
Inspired by the relatively simple morphological blueprint provided by batoid fish such as
stingrays and skates, we created a biohybrid system that enables an artificial animal—a …
stingrays and skates, we created a biohybrid system that enables an artificial animal—a …
Crystal structure of Zika virus NS2B-NS3 protease in complex with a boronate inhibitor
The ongoing Zika virus (ZIKV) outbreak is linked to severe neurological disorders. ZIKV
relies on its NS2B/NS3 protease for polyprotein processing; hence, this enzyme is an …
relies on its NS2B/NS3 protease for polyprotein processing; hence, this enzyme is an …
Molecular biology of flaviviruses
BD Lindenbach, CM Rice - Advances in virus research, 2003 - books.google.com
The major medical importance of flaviviruses has fostered studies into their molecular
biology in research laboratories around the world. Although the molecular biology of …
biology in research laboratories around the world. Although the molecular biology of …
Ten years of dengue drug discovery: progress and prospects
To combat neglected diseases, the Novartis Institute of Tropical Diseases (NITD) was
founded in 2002 through private–public funding from Novartis and the Singapore Economic …
founded in 2002 through private–public funding from Novartis and the Singapore Economic …
Structure of the NS2B-NS3 protease from Zika virus after self-cleavage
The recent outbreak of Zika virus (ZIKV) infections in the Americas represents a serious
threat to the global public health. The viral protease that processes viral polyproteins during …
threat to the global public health. The viral protease that processes viral polyproteins during …
Molecular evolution of dengue viruses: contributions of phylogenetics to understanding the history and epidemiology of the preeminent arboviral disease
SC Weaver, N Vasilakis - Infection, genetics and evolution, 2009 - Elsevier
Dengue viruses (DENV) are the most important arboviral pathogens in tropical and
subtropical regions throughout the world, putting at risk of infection nearly a third of the …
subtropical regions throughout the world, putting at risk of infection nearly a third of the …
Seeking heterocyclic scaffolds as antivirals against dengue virus
Dengue is one of the most typical viral infection categorized in the Neglected Tropical
Diseases (NTDs). It is transmitted via the female Aedes aegypti mosquito to humans and …
Diseases (NTDs). It is transmitted via the female Aedes aegypti mosquito to humans and …
Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus
P Erbel, N Schiering, A D'Arcy, M Renatus… - Nature structural & …, 2006 - nature.com
The replication of flaviviruses requires the correct processing of their polyprotein by the viral
NS3 protease (NS3pro). Essential for the activation of NS3pro is a 47-residue region of …
NS3 protease (NS3pro). Essential for the activation of NS3pro is a 47-residue region of …