Adult neurogenesis is a multistage process by which neurons are generated and integrated
into existing neuronal circuits. In the adult brain, neurogenesis is mainly localized in two …

Nuclear factor erythroid 2-related factor 2 (Nrf2) is ubiquitously expressed in most eukaryotic
cells and functions to induce a broad range of cellular defenses against exogenous and …

Neurodegenerative diseases (NDs) cause progressive loss of neurons in nervous system.
NDs are categorized as acute NDs such as stroke and head injury, besides chronic NDs …

The aryl hydrocarbon receptor (AhR) has long been implicated in the induction of a battery
of genes involved in the metabolism of xenobiotics and endogenous compounds. AhR is a …

Neurodegenerative diseases are characterized by the loss of homeostatic functions that
control redox and energy metabolism, neuroinflammation, and proteostasis. The …

Oxidative stress has been implicated in the etiology and pathobiology of various
neurodegenerative diseases. At baseline, the cells of the nervous system have the capability …

Myelin sheaths in the central nervous system (CNS) insulate axons and thereby allow
saltatory nerve conduction, which is a prerequisite for complex brain function. Multiple …

Neurogenesis occurs in the brain during embryonic development and throughout adulthood.
Neurogenesis occurs in the hippocampus and under normal conditions and persists in two …

Friedreich ataxia (FA) is an inherited autosomal recessive neurodegenerative disease
(NDD) characterized primarily by progressive sensory and spinocerebellar ataxia …

Nuclear factor erythroid 2-related factor 2 (Nrf2) is an important transcription factor that
reduces oxidative stress. When reactive oxygen species (ROS) or reactive nitrogen species …