Diastereoselective synthesis of 2,5-disubstituted tetrahydrofurans - ScienceDirect Skip to main
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In the last years ruthenium tetroxide is increasingly being used in organic synthesis. Thanks
to the fine tuning of the reaction conditions, including pH control of the medium and the use …

Since its introduction into organic chemistry more than fifty years ago, RuO 4 has been used
mainly as a strong oxidizing agent. Owing to its high reactivity, catalytic reactions employing …

Conclusion In summary, this review article has illustrated the application of three-component
coupling reactions, core expansion and dimerization strategies that have greatly simplified …

cis-2, 5-Disubstituted tetrahydrofurans constitute the core of several natural products and
synthetic analogues which exhibit a broad and interesting range of biological activities. This …

During the last forty years, several groups have reported results concerning the oxidative
cyclization of polyenes, mostly dienes, with transition-metal-oxo species such as …

The configuration of the penta-tetrahydrofuranyl diol (penta-THF) product obtained by a
single-step, RuO4-catalyzed oxidative polycyclization of squalene, has been determined as …

Further studies on the RuO4-catalyzed oxidative polycyclization of isoprenoid polyenes
have been carried out. The configuration of the tris-THF product from the oxidation of …

Ruthenium tetroxide (1 mol%) has been used as a catalyst for the oxidative mono-cyclization
of 1, 5, 9-trienes and polyenes. The poly-unsaturated substrates underwent mono …

The iodocyclization of γ, δ-unsaturated alcohols in the presence of a silyl enol ether
produced cis-2, 5-disubstituted tetrahydrofurans in one pot via siloxy intermediates. N …