Severe cardiac remodeling leading to heart failure in individuals harboring pathogenic
LMNA variants, known as cardiolaminopathy, poses a significant clinical challenge …

Continuing advances in genomics, molecular and cellular mechanobiology and
immunobiology, including transcriptomics and proteomics, and biomechanics increasingly …

During the Ross procedure, an aortic heart valve is replaced by a patient's own pulmonary
valve. The pulmonary autograft subsequently undergoes substantial growth and remodeling …

Blood vessels grow and remodel in response to mechanical stimuli. Many computational
models capture this process phenomenologically, by assuming stress homeostasis, but this …

Mechanical stimuli experienced by vascular smooth muscle cells (VSMCs) and
mechanosensitive Notch signaling are important regulators of vascular growth and …

The extracellular matrix (ECM) provides a dynamic microenvironment for cells, which has
time-responsive mechanical properties such as hysteresis, relaxation, and creep …

The transplantation of vascular grafts has emerged as a prevailing approach to address
vascular disorders. However, the development of small-diameter vascular grafts is still in …

Constrained mixture models have successfully simulated many cases of growth and
remodeling in soft biological tissues. So far, extensions of these models have been …

To successfully engineer large-sized tissues, establishing vascular structures is essential for
providing oxygen, nutrients, growth factors and cells to prevent necrosis at the core of the …

The endothelialization of cardiovascular implants is supposed to improve the long-term
patency of these implants. In addition, in previous studies, it has been shown, that the …