Evidence implicating Eph receptor tyrosine kinases and their ephrin ligands (that together
make up the 'Eph system') in cancer development and progression has been accumulating …

Eph receptors are the largest family of receptor tyrosine kinases and mediate a myriad of
essential processes in humans from embryonic development to adult tissue homeostasis …

The Eph receptors are the largest of the RTK families. Like other RTKs, they transduce
signals from the cell exterior to the interior through ligand-induced activation of their kinase …

DNMT3A, the gene encoding the de novo DNA methyltransferase 3A, is among the most
frequently mutated genes in hematologic malignancies. However, the mechanisms through …

Fmr1 knock-out (ko) mice display key features of fragile X syndrome (FXS), including
delayed dendritic spine maturation and FXS-associated behaviors, such as poor …

Identification of germinal center (GC) B cells is typically reliant on the use of surface
activation markers that exhibit a wide range of expression. Here, we identify Ephrin-B1, a …

Gonadotoxic chemotherapeutics, such as cyclophosphamide, can cause early menopause
and infertility in women. Earlier histological studies showed ovarian reserve depletion via …

In life, genetic and epigenetic networks precisely coordinate the expression of genes—but in
death, it is not known if gene expression diminishes gradually or abruptly stops or if specific …

Mesenchymal stromal/stem cells (MSC) express the contact-dependent erythropoietin-
producing hepatocellular (Eph) receptor tyrosine kinase family and their cognate ephrin …

Cancer cells rely on intercellular communication throughout the different stages of their
transformation and progression into metastasis. They do so by co-opting different processes …