Discovery of the myogenic regulatory factor family of transcription factors MYF5, MYOD,
Myogenin and MRF4 was a seminal step in understanding specification of the skeletal …

Increasing evidence points to extracellular matrix (ECM) components playing integral roles
in regulating the muscle satellite cell (SC) niche. Even small alterations to the niche ECM …

Progress toward finding a cure for muscle diseases has been slow because of the absence
of relevant cellular models and the lack of a reliable source of muscle progenitors for …

Urodele amphibians regenerate appendages through the recruitment of progenitor cells into
a blastema that rebuilds the lost tissue. Blastemal formation is accompanied by extensive …

This paper looks at the effects of aging on the response of skeletal muscle to exercise from
the perspective of the behavior of muscle precursor cells (widely termed satellite cells or …

The role of tumor necrosis factor-alpha (TNF-α), an important mediator of the inflammatory
response after injury, was investigated in regenerating skeletal muscle. The pattern of …

Skeletal muscle relies upon regeneration to maintain homeostasis and repair injury. This
process involves the recruitment of the tissue's resident stem cell, the muscle progenitor cell …

Skeletal muscle tissue engineering still does not result in the desired functional properties
and texture as preferred for regenerative medicine and meat production applications …

Because of its mechanical function, skeletal muscle is heavily influenced by the composition
of its extracellular matrix (ECM). Fibrosis generated by chronic damage, such as occurs in …

Cultured meat is a potential sustainable food generated by the in vitro myogenesis of muscle
satellite (stem) cells (MSCs). The self-renewal and differentiation properties of MSCs are of …