Gene–environment interactions in Alzheimer disease: the emerging role of epigenetics
L Migliore, F Coppedè - Nature Reviews Neurology, 2022 - nature.com
With the exception of a few monogenic forms, Alzheimer disease (AD) has a complex
aetiology that is likely to involve multiple susceptibility genes and environmental factors. The …
aetiology that is likely to involve multiple susceptibility genes and environmental factors. The …
Neurodegenerative and neurological disorders by small inhaled particles
HJ Heusinkveld, T Wahle, A Campbell, RHS Westerink… - Neurotoxicology, 2016 - Elsevier
The world⿿ s population is steadily ageing and as a result, health conditions related to
ageing, such as dementia, have become a major public health concern. In 2001, it was …
ageing, such as dementia, have become a major public health concern. In 2001, it was …
Molecular basis of familial and sporadic Alzheimer's disease
J Dorszewska, M Prendecki… - Current Alzheimer …, 2016 - ingentaconnect.com
Alzheimer's disease (AD) is a multifactorial disease with genetic (70%) and environmental
(30%) causes. Among the genetic factors are genes associated with a family history of the …
(30%) causes. Among the genetic factors are genes associated with a family history of the …
The epigenetics of aging and neurodegeneration
Epigenetics is a quickly growing field encompassing mechanisms regulating gene
expression that do not involve changes in the genotype. Epigenetics is of increasing …
expression that do not involve changes in the genotype. Epigenetics is of increasing …
Histone acetylation: molecular mnemonics on the chromatin
Long-lasting memories require specific gene expression programmes that are, in part,
orchestrated by epigenetic mechanisms. Of the epigenetic modifications identified in …
orchestrated by epigenetic mechanisms. Of the epigenetic modifications identified in …
Metals and neurodegenerative diseases. A systematic review
CE Cicero, G Mostile, R Vasta, V Rapisarda… - Environmental …, 2017 - Elsevier
Neurodegenerative processes encompass a large variety of diseases with different
pathological patterns and clinical presentation such as Amyotrophic Lateral Sclerosis (ALS) …
pathological patterns and clinical presentation such as Amyotrophic Lateral Sclerosis (ALS) …
[HTML][HTML] Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer's disease patients
L Chouliaras, D Mastroeni, E Delvaux, A Grover… - Neurobiology of …, 2013 - Elsevier
Epigenetic dysregulation of gene expression is thought to be critically involved in the
pathophysiology of Alzheimer's disease (AD). Recent studies indicate that DNA methylation …
pathophysiology of Alzheimer's disease (AD). Recent studies indicate that DNA methylation …
Systemic immune challenges trigger and drive Alzheimer-like neuropathology in mice
D Krstic, A Madhusudan, J Doehner, P Vogel… - Journal of …, 2012 - Springer
Background Alzheimer's disease (AD) is the most prevalent form of age-related dementia,
and its effect on society increases exponentially as the population ages. Accumulating …
and its effect on society increases exponentially as the population ages. Accumulating …
Maternal immune activation results in complex microglial transcriptome signature in the adult offspring that is reversed by minocycline treatment
Maternal immune activation (MIA) during pregnancy has been linked to an increased risk of
developing psychiatric pathologies in later life. This link may be bridged by a defective …
developing psychiatric pathologies in later life. This link may be bridged by a defective …
Global changes in DNA methylation and hydroxymethylation in Alzheimer's disease human brain
N Coppieters, BV Dieriks, C Lill, RLM Faull… - Neurobiology of …, 2014 - Elsevier
Abstract DNA methylation (5-methylcytosine [5mC]) is one of several epigenetic markers
altered in Alzheimer's disease (AD) brain. More recently, attention has been given to DNA …
altered in Alzheimer's disease (AD) brain. More recently, attention has been given to DNA …