Promising reagents for difluoroalkylation

DQ Dong, H Yang, JL Shi, WJ Si, ZL Wang… - Organic Chemistry …, 2020 - pubs.rsc.org
This review describes recent advances in difluoroalkylation reactions using different
substrates. Generally speaking, RCF2 radical is generally proposed in the mechanism of …

Decoding directing groups and their pivotal role in C− H activation

K Murali, LA Machado, RL Carvalho… - … A European Journal, 2021 - Wiley Online Library
Synthetic organic chemistry has witnessed a plethora of functionalization and
defunctionalization strategies. In this regard, C− H functionalization has been at the forefront …

Antileishmanial activity of 4-phenyl-1-[2-(phthalimido-2-yl) ethyl]-1H-1, 2, 3-triazole (PT4) derivative on Leishmania amazonensis and Leishmania braziliensis: In silico …

VN Holanda, WV da Silva, PH do Nascimento… - Bioorganic …, 2020 - Elsevier
Organic compounds obtained by click chemistry reactions have demonstrated a broad
spectrum of biological activities being widely applied for the development of molecules …

Merocyanines: Electronic Structure and Spectroscopy in Solutions, Solid State, and Gas Phase

AV Kulinich, AA Ishchenko - Chemical Reviews, 2024 - ACS Publications
Merocyanines, owing to their readily tunable electronic structure, are arguably the most
versatile functional dyes, with ample opportunities for tailored design via variations of both …

Synthetic approaches to biologically active C-2-substituted benzothiazoles

BA Shainyan, LV Zhilitskaya, NO Yarosh - Molecules, 2022 - mdpi.com
Numerous benzothiazole derivatives are used in organic synthesis, in various industrial and
consumer products, and in drugs, with a wide spectrum of biological activity. As the …

Cu-catalyzed direct C1− H difluoromethylation of pyrrolo [1, 2-a] quinoxalines

Y Li, Z Yang, Y Liu, Y Liu, Y Gu, P Liu - Molecular Catalysis, 2021 - Elsevier
An efficient Cu-catalyzed direct C1− H difluoromethylation of pyrrolo [1, 2-a] quinoxalines
with BrCF 2 CO 2 Et or BrCF 2 CONEt 2 has been reported, providing to a series of …

Copper-Catalyzed Difluoroalkylation Reaction

DQ Dong, SH Yang, P Wu, JZ Wang, LH Min, H Yang… - Molecules, 2022 - mdpi.com
This review describes recent advances in copper-catalyzed difluoroalkylation reactions. The
RCF2 radical is generally proposed in the mechanism of these reactions. At present, various …

Investigations into a change of aryl group on the cytotoxicity and anti-leishmanial activity of a series of tris-aryl Sb (V) pentafluoropropionates

EV Artem'eva, RN Duffin, S Munuganti, AN Efremov… - Polyhedron, 2022 - Elsevier
Five tris-arylantimony bis (pentafluoropropionates) of the general formula Ar 3 Sb [OC (O)
CF 2 CF 3] 2 with Ar= Ph (1), m-Tol,(2) p-Tol (3), C 6 H 4 F-4 (4), C 6 H 3-OMe-2-Br-5 (5) …

Synthesis, biological evaluation and mechanism of action of benzothiazole derivatives with aromatic hydrazone moiety, a new class of antileishmanial compounds

ES Coimbra, LMR Antinarelli… - Chemical Biology & …, 2024 - Wiley Online Library
Leishmaniasis is a disease caused by protozoa Leishmania spp., considered as a
significant and urgent public health problem mainly in developing countries. In the absence …

Light-mediated catalytic enantioselective difluoroalkylation of β-ketoesters via phase-transfer catalysis

CE Adams, CP Johnston - Organic Chemistry Frontiers, 2024 - pubs.rsc.org
We report a phase-transfer-catalysed asymmetric α-difluoroalkylation of β-ketoesters
through visible light-promoted radical generation. This methodology affords quaternary …