Age-associated B cells (ABCs) are a transcriptionally and functionally unique B cell
population. In addition to arising with age and following infection, ABCs are expanded …

Aims Aging is a dominant driver of atherosclerosis and induces a series of immunological
alterations, called immunosenescence. Given the demographic shift towards elderly …

Random VDJ recombination early in T and B cell development enables the adaptive
immune system to recognize a vast array of evolving pathogens via antigen receptors …

B cells are key pathogenic drivers of chronic inflammation in rheumatoid arthritis (RA). There
is limited understanding of the relationship between synovial B cell subsets and pathogenic …

Viral mimicry of host cell structures has been postulated to curtail the B cell receptor (BCR)
repertoire against persisting viruses through tolerance mechanisms. This concept awaits …

Alloreactivity can drive autoimmune syndromes. After allogeneic hematopoietic stem cell
transplantation (allo-HCT), chronic graft-versus-host disease (cGVHD), a B cell–associated …

The establishment of aging clocks highlighted the strong link between changes in DNA
methylation and aging. Yet, it is not known if other epigenetic features could be used to …

B cells are one of the fundamental components of the adaptive immune system and are best
known for their ability to produce antibodies. Among the various types of inborn errors of …

Mice deficient in Lyn, a tyrosine kinase that limits B cell activation, develop a lupus-like
autoimmune disease characterized by the accumulation of splenic plasma cells and the …

This study aimed at defining the role of the B cell adaptor protein BANK1 in the appearance
of age-associated B cells (ABCs) in 2 SLE mouse models (TLR7. tg6 and imiquimod …