Inhibition of gene expression in human cells using RNase P-derived ribozymes and external guide sequences
K Kim, F Liu - Biochimica et Biophysica Acta (BBA)-Gene Structure …, 2007 - Elsevier
Ribonuclease P (RNase P) complexed with an external guide sequence (EGS) represents a
novel nucleic acid-based gene interference approach to modulate gene expression. This …
novel nucleic acid-based gene interference approach to modulate gene expression. This …
Multidimensional futuristic approaches to address the pandemics beyond COVID-19
SB Kotwal, N Orekondey, GP Saradadevi… - Heliyon, 2023 - cell.com
Globally, the impact of the coronavirus disease 2019 (COVID-19) pandemic has been
enormous and unrelenting with∼ 6.9 million deaths and∼ 765 million infections. This …
enormous and unrelenting with∼ 6.9 million deaths and∼ 765 million infections. This …
The discovery of a catalytic RNA within RNase P and its legacy
Sidney Altman's discovery of the processing of one RNA by another RNA that acts like an
enzyme was revolutionary in biology and the basis for his sharing the 1989 Nobel Prize in …
enzyme was revolutionary in biology and the basis for his sharing the 1989 Nobel Prize in …
Destroying RNA as a therapeutic approach
A Tafech, T Bassett, D Sparanese… - Current medicinal …, 2006 - ingentaconnect.com
The ability to target RNA, mRNA and viral RNA in particular, for degradation is a powerful
approach in molecular biology and pharmacology. Such approaches can be used in the …
approach in molecular biology and pharmacology. Such approaches can be used in the …
[HTML][HTML] Engineering of RNase P Ribozymes for Therapy against Human Cytomegalovirus Infection
A Smith, I Zhang, P Trang, F Liu - Viruses, 2024 - mdpi.com
Nucleic acid-based gene interference and editing strategies, such as antisense
oligonucleotides, ribozymes, RNA interference (RNAi), and CRISPR/Cas9 coupled with …
oligonucleotides, ribozymes, RNA interference (RNAi), and CRISPR/Cas9 coupled with …
Inhibition of respiratory syncytial virus in cultured cells by nucleocapsid gene targeted deoxyribozyme (DNAzyme)
YY Xie, XD Zhao, LP Jiang, HL Liu, LJ Wang, P Fang… - Antiviral research, 2006 - Elsevier
Respiratory syncytial virus (RSV), which presents the primary cause of bronchiolitis and
pneumonia among infants and causes significant morbidity and mortality in immunodeficient …
pneumonia among infants and causes significant morbidity and mortality in immunodeficient …
RNase P ribozyme effectively inhibits human CC-chemokine receptor 5 expression and human immunodeficiency virus 1 infection
B Yan, Y Liu, YC Chen, I Zhang, F Liu - Zoonotic Diseases, 2023 - mdpi.com
Simple Summary Acquired immunodeficiency syndrome (AIDS), which is caused by human
immunodeficiency virus (HIV), is a significant global public health concern. It is critical to …
immunodeficiency virus (HIV), is a significant global public health concern. It is critical to …
Effective inhibition in animals of viral pathogenesis by a ribozyme derived from RNase P catalytic RNA
Y Bai, P Trang, H Li, K Kim… - Proceedings of the …, 2008 - National Acad Sciences
A functional RNase P ribozyme (M1GS RNA) was constructed to target the overlapping
mRNA region of two murine cytomegalovirus (MCMV) capsid proteins essential for viral …
mRNA region of two murine cytomegalovirus (MCMV) capsid proteins essential for viral …
Strategies to identify potential therapeutic target sites in RNA
M Lützelberger, J Kjems - RNA Towards Medicine, 2006 - Springer
Antisense agents are powerful tools to inhibit gene expression in a sequencespecific
manner. They are used for functional genomics, as diagnostic tools and for therapeutic …
manner. They are used for functional genomics, as diagnostic tools and for therapeutic …
Effective inhibition of human cytomegalovirus gene expression and growth by intracellular expression of external guide sequence RNA
H Li, P Trang, K Kim, T Zhou, S Umamoto, F Liu - Rna, 2006 - rnajournal.cshlp.org
RNase P complexed with external guide sequence (EGS) represents a novel nucleic-acid-
based gene interference approach to modulate gene expression. In this study, a functional …
based gene interference approach to modulate gene expression. In this study, a functional …