Parkinson's disease (PD) is clinically, pathologically, and genetically heterogeneous,
resisting distillation to a single, cohesive disorder. Instead, each affected individual develops …

Parkinson's disease (PD) is a growing cause of disability worldwide and there is a critical
need for the development of disease-modifying therapies to slow or stop disease …

Exocytosis and endocytosis are essential physiological processes and are of prime
importance for brain function. Neurotransmission depends on the Ca 2+-triggered …

Autophagy is a cellular degradation pathway essential for neuronal health and function.
Autophagosome biogenesis occurs at synapses, is locally regulated, and increases in …

Lipid interaction with α-synuclein (αSyn) has been long implicated in the pathogenesis of
Parkinson's disease (PD). However, it has not been fully determined which lipids are …

This mini-review aims to summarize a growing body of literature on synaptojanin 1 (Synj1), a
phosphoinositide phosphatase that was initially known to have a prominent role in synaptic …

Abstract Purpose of Review Parkinson's disease (PD) is a common neurodegenerative
disease, which can cause progressive deterioration of motor function causing muscle …

Autophagy is an evolutionary conserved catabolic pathway essential for the maintenance of
cellular homeostasis. Defective proteins and organelles are engulfed by autophagosomal …

α-Synuclein (α-Syn) is a protein implicated in the pathogenesis of Parkinson's disease (PD).
It is an intrinsically disordered protein that binds acidic phospholipids. Growing evidence …

The progressive aging of the population and the fact that Parkinson's disease currently does
not have any curative treatment turn out to be essential issues in the following years, where …