Background Millennia of directional human selection has reshaped the genomic architecture
of cultivated cotton relative to wild counterparts, but we have limited understanding of the …

Genome-wide association study (GWAS) is the most popular approach to dissecting
complex traits in plants, humans, and animals. Numerous methods and tools have been …

Difficulty in detecting rare variants is one of the problems in conventional genome-wide
association studies (GWAS). The problem is closely related to the complex gene …

Set tests are a powerful approach for genome-wide association testing between groups of
genetic variants and quantitative traits. We describe mtSet (http://github. com/PMBio/limix), a …

Genetic analysis in autopolyploids is a very complicated subject due to the enormous
number of genotypes at a locus that needs to be considered. For instance, the number of... In …

Background—The P wave on an ECG is a measure of atrial electric function, and its
characteristics may serve as predictors for atrial arrhythmias. Increased mean P-wave …

Linear mixed models (LMMs) and their extensions have recently become the method of
choice in phenotype prediction for complex traits. However, LMM use to date has typically …

Many traits, such as height, the response to a given drug, or the susceptibility to certain
diseases are presumably co-determined by genetics. Especially in the field of medicine, it is …

Here we present an exome-wide rare genetic variant association study for 30 blood
biomarkers in 191,971 individuals in the UK Biobank. We compare gene-based association …

Recent algorithmic advancements have enabled the inference of genome-wide ancestral
recombination graphs (ARGs) from genomic data in large cohorts. These inferred ARGs …