[HTML][HTML] Radiopharmaceutical therapy in cancer: clinical advances and challenges

G Sgouros, L Bodei, MR McDevitt… - Nature reviews Drug …, 2020 - nature.com
Radiopharmaceutical therapy (RPT) is emerging as a safe and effective targeted approach
to treating many types of cancer. In RPT, radiation is systemically or locally delivered using …

Fluorescent chemical probes for accurate tumor diagnosis and targeting therapy

M Gao, F Yu, C Lv, J Choo, L Chen - Chemical Society Reviews, 2017 - pubs.rsc.org
Surgical resection of solid tumors is currently the gold standard and preferred therapeutic
strategy for cancer. Chemotherapy drugs also make a significant contribution by inhibiting …

Low-dose targeted radionuclide therapy renders immunologically cold tumors responsive to immune checkpoint blockade

RB Patel, R Hernandez, P Carlson… - Science translational …, 2021 - science.org
Molecular and cellular effects of radiotherapy on tumor microenvironment (TME) can help
prime and propagate antitumor immunity. We hypothesized that delivering radiation to all …

Beyond the margins: real-time detection of cancer using targeted fluorophores

RR Zhang, AB Schroeder, JJ Grudzinski… - Nature reviews Clinical …, 2017 - nature.com
Over the past two decades, synergistic innovations in imaging technology have resulted in a
revolution in which a range of biomedical applications are now benefiting from fluorescence …

[HTML][HTML] The promise of combining radiation therapy with immunotherapy

JC Jagodinsky, PM Harari, ZS Morris - International Journal of Radiation …, 2020 - Elsevier
The development of immunotherapy in oncology builds upon many years of scientific
investigation into the cellular mechanics underlying interactions between tumor cells and …

[HTML][HTML] A bright future for precision medicine: advances in fluorescent chemical probe design and their clinical application

M Garland, JJ Yim, M Bogyo - Cell chemical biology, 2016 - cell.com
The Precision Medicine Initiative aims to use advances in basic and clinical research to
develop therapeutics that selectively target and kill cancer cells. Under the same doctrine of …

[HTML][HTML] Fluorescence-guided surgery: a review on timing and use in brain tumor surgery

AJ Schupper, M Rao, N Mohammadi, R Baron… - Frontiers in …, 2021 - frontiersin.org
Fluorescence-guided surgery (FGS) allows surgeons to have improved visualization of
tumor tissue in the operating room, enabling maximal safe resection of malignant brain …

Radiotheranostics in cancer diagnosis and management

H Jadvar, X Chen, W Cai, U Mahmood - Radiology, 2018 - pubs.rsna.org
The fundamental foundation for precision medicine is accurate and specific targeting of
cancer cells. Advances in the understanding of cancer biology, developments in diagnostic …

[HTML][HTML] Temporal analysis of type 1 interferon activation in tumor cells following external beam radiotherapy or targeted radionuclide therapy

JC Jagodinsky, WJ Jin, AM Bates, R Hernandez… - Theranostics, 2021 - ncbi.nlm.nih.gov
Rationale: Clinical interest in combining targeted radionuclide therapies (TRT) with
immunotherapies is growing. External beam radiation therapy (EBRT) activates a type 1 …

[HTML][HTML] Clinical advances and perspectives in targeted radionuclide therapy

N Lepareur, B Ramée, M Mougin-Degraef… - Pharmaceutics, 2023 - mdpi.com
Targeted radionuclide therapy has become increasingly prominent as a nuclear medicine
subspecialty. For many decades, treatment with radionuclides has been mainly restricted to …